Rar-related orphan receptor gamma-t

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 13.06.2021

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Synonym(s)

ROR-gamma-t

Definition
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Acronym for "RAR-related orphan receptor gamma-t". RAR-related orphan receptor gamma-t (RORgamma-T; RORγt) is a DNA-binding transcription factor, a member of the NR1 subfamily of "nuclear receptors". RORgamma-T, together with its isoform RORgamma1, is encoded by the RORC gene.

The transcription factor is substantially expressed by immature CD4+(Th17 cells) and CD8+ lymphocytes organized in the thymus. The RAR-related orphan receptor gamma-t plays an important role in lymphoid tissue organogenesis in lymph nodes, Peyer's plaques, but not in the spleen. It is important for thymopoiesis by inhibiting apoptosis of undifferentiated T cells on the one hand and promoting their differentiation into Th17 cells on the other hand.

Note(s)
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The protein plays an important role in the pathogenesis of psoriasis and rheumatoid arthritis. Inhibitors of ROR-gamma-t in development appear to be promising in their efficacy.

Literature
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  1. Eberl G e al. (2004) Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science 305: 248-251.
  2. Huang Z et al (2007) Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity.Expert Opin Ther Targets 11:737-743.
  3. Preitner N et al (2002) "The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator". Cell 110: 251-260.
  4. Schäkel K et al (2016) Pathogenesis of psoriasis vulgaris. Dermatologist 67: 422-432
  5. Sun Z et al (2000) Requirement for RORgamma in thymocyte survival and lymphoid organ development". Science 288: 2369-2373.

Outgoing links (4)

Apoptosis; Cd4; Cd8; Th17 lymphocyte;

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Last updated on: 13.06.2021