pseudoangioedema

Pseudoangioedema refers to acute swelling of the skin or mucosa that clinically resembles angioedema. They differ from these in their different etiopathogenesis, as they are not based on a histamine- or bradykinin-mediated mechanism.

Examples of non-histamine and bradykinin mediated pseudoangioedema are:

• ACE angioedema ( T73.3) (captopril, enalapril, ramipril)
• Sartan angioedema/sartans= At1 blockers (candesartan, losartan)
• NSAIDs-angioedema (T73.3/e.g. aspirin)
• mTOR inhibitor-induced angioedema (sirolimus, everolimus) (Beaini H et al.2024)
• Tyrosine kinase inhibitors (e.g. dasatinib/Nyckowski T et al. 2022)
• Antipsychotics (e.g. olanzapine/Malhotra M et al. 2013),
• Neuroleptics such as risperidone (periorbial swelling/Pelizza L 2008)
• Angioedema after biologics (e.g. dupilumab as an anti-IL4 receptor blocker)