Progeria (overview) E34.8

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 26.10.2021

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Aging Syndrome

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Heterogeneous group of hereditary diseases (aging syndromes), which are clinically characterized by pathological, premature aging (see also skin aging) with atrophic, wrinkled skin. Poikiloderma or scleroderma-like changes may be present. Differentiation between generalized and localized clinical pictures.

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Clinically, the following (genetically different) syndromes can be summarized, whose clinical commonality is given by the premature aging of the patients:

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No causal therapy known. Nursing externals. Symptomatic therapy according to the respective appearance, see also there.

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  1. Chu Y et al (2015) Hutchinson-Gilford progeria syndrome caused by anLMNA mutation: a case report. Pediatr Dermatol 32:271-275
  2. Gilkes JJH et al (1974) The premature ageing syndromes. Br J Dermatol. 91: 243-262
  3. Johnston J et al (2015) A point mutation in PDGFRB causes autosomal-dominant penttinen syndrome. Am J Hum Genet 97: 465-474.

  4. Miyamoto MI et al (2014) Atherosclerosis in ancient humans, accelerated aging syndromes and normal aging: is lamin a protein a common link? Glob Heart 9:211-218


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Last updated on: 26.10.2021