Metagerie E34.87

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

All authors of this article

Last updated on: 29.10.2020

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History
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Gottron, 1940; Gilkes, Sharvill and Wells, 1974

Definition
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Probably autosomal recessive inherited, premature aging syndrome in high-flown juvenile diabetics.

Clinical features
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Bird face, atrophic skin and spotted hyperpigmentation and telangiectasia of the extremities. Thin, sparse hair, loss of subcutaneous fatty tissue, canities praecox, cataract formation.

Complication(s)
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Premature arteriosclerosis.

Therapy
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No causal therapy known.

Literature
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  1. Blaszczyk M et al (2000) Acrogeria of the Gottron type in a mother and son. Eur J Dermatol 10: 36-40
  2. Gilkes JJH, Sharvill DE, Wells RS (1974) The premature ageing syndromes: report of eight cases and description of a new entity named metageria. Br J Dermatol 91: 243-262
  3. Gottron H (1940) Family Acrogerie. Arch Derm Syph 181: 571-583
  4. Greally JM et al (1992) Acrometageria: a spectrum of premature aging syndromes. At J Med Genet 44: 334-339
  5. Winkelspecht K et al (1997) Metageria--clinical manifestations of a premature aging syndrome. dermatologist 48: 657-661

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