Povidone-iodine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Polyvidonum-Iodine; Polyvinylpyrrolidone-iodine; Polyvinylpyrrolidonum-iodine; Povidone-iodine; PVP Iodine; PVP-iodine (INCI)

Definition
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Disinfection. Consists of polyvinylpyrrolidone of different chain length and contains iodine in a complex bond. Seiendesifying effect is ultimately based on the effect of free iodine.

The substance is soluble in water and ethanol, but not in acetone and ether.

Indication
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Superficial skin and mucous membrane infections, burns.

Limited indication
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Pregnancy, infants < 6 months, thyroid diseases.

Dosage and method of use
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  • Solution/Cream/Ointment/Gel: Apply once/day to the affected areas.
  • For infections in the vaginal area: 1 vaginal suppository of 200 mg or an applicator filling (5 g) of the 10% gel should be inserted deep into the vagina.

Standard concentration
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  • 1% solution for flushing body cavities.
  • 7.5% solution for mouth rinsing.
  • 3,25-10% solution/cream/ointment/gel.

Undesirable effects
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Allergic reactions ( contact allergy). Povidone-iodine is a common contact allergen in the IVDK collective. The substance has a high irritant potential (Ammann PM et al. 2018).

Pain when applied to the wounds, metabolic acidosis, electrolyte disorders, hyperthyroidism, thyrotoxicosis (in case of latent thyroid dysfunction), renal insufficiency, delayed wound healing.

Anaphylactic reactions have also been described to the carrier substance (see below polyvinylpyrrolidone).

Interactions
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Topical IFN (denaturation of IFN), highly local toxic reactions and burns caused by mercury compounds.

Contraindication
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Lactation, iodine allergy, dermatitis herpetiformis, radioiodine therapy, acne vulgaris.

Preparations
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Betaisodona, Traumasept

Literature
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  1. Ammann PM et al (2018) Disinfectants. Allergo J 27:16-18

Authors

Last updated on: 29.10.2020