DefinitionThis section has been translated automatically.
Gastro-resistant, non-betalactamase-resistant betalactam antibiotic(penicillin) with good efficacy against gram-positive germs. Penicillin V was introduced in 1953 as the first acid-stable penicillin suitable for oral administration.
Half-lifeThis section has been translated automatically.
You might also be interested in
Spectrum of actionThis section has been translated automatically.
The mechanism of action of phenoxymethylpenicillin, as with all penicillins, is based on an inhibition of bacterial cell wall synthesis (in the growth phase) by blocking the penicillin-binding proteins. This results in a bactericidal effect.
Usually sensitive species:
Aerobic Gram-positive microorganisms
Streptococcus dysgalactiae subsp. equisimilis
(Streptococci groups C and G)
Streptococci of the "Viridans" group
Aerobic Gram-negative microorganisms
IndicationThis section has been translated automatically.
Dosage and method of useThis section has been translated automatically.
- Adults and children over 12 years: 1,5-8 mio IU/day p.o. in 3 ED.
- Children 6-12 years: 40-60.000 IU/kg KG 3 times/day p.o.
- Children 1-5 years: 15-20.000 IU/kg KG 3 times/day.
- Infants: 15-20.000 IU/kg KG 3 times/day.
PreparationsThis section has been translated automatically.
Note(s)This section has been translated automatically.
With proven sensitivity, penicillin V has a 10 to 100 times stronger effect against staphylococci than staphylococci penicillins.
Due to its acid stability, phenoxymethylpenicillin is absorbed in the upper sections of the small intestine after largely loss-free passage through the stomach. The resorption rate is about 60%. The extent of absorption also depends on the galenic form. Solid dosage forms are less problematic than granulates for the preparation of a solution/suspension.
1 mg phenoxymethylpenicillin corresponds to 1695 I.U.
LiteratureThis section has been translated automatically.
- Wright GD (2007) Biochemistry. A new target for antibiotic development. Science 315: 1373-1374