Penicillin v

Last updated on: 29.10.2020

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Synonym(s)

6-(Phenoxyacetylamino) -penicillanic acid; CAS number: 87-08-1; Penicillin V; Phenoxymethylpenicilliin; Phenoxymethyl penicillin; Phenoxymethylpenicillinum

Definition
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Gastro-resistant, non-betalactamase-resistant betalactam antibiotic(penicillin) with good efficacy against gram-positive germs. Penicillin V was introduced in 1953 as the first acid-stable penicillin suitable for oral administration.

Half-life
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0,5 h

Spectrum of action
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The mechanism of action of phenoxymethylpenicillin, as with all penicillins, is based on an inhibition of bacterial cell wall synthesis (in the growth phase) by blocking the penicillin-binding proteins. This results in a bactericidal effect.

Usually sensitive species:

Aerobic Gram-positive microorganisms

Actinomyces israelii

corynebacterium diphtheriae

Erysipelothrix rhusiopathiae

gardnerella vaginalis

streptococcus agalactiae

streptococcus pneumoniae

streptococcus pyogenes

Streptococcus dysgalactiae subsp. equisimilis

(Streptococci groups C and G)

Streptococci of the "Viridans" group

Aerobic Gram-negative microorganisms

Borrelia burgdorferi

Eikenella corrodens

Haemophilus influenzae

Anaerobic microorganisms

Clostridium perfringens

Clostridium tetani

Fusobacterium spp.

Peptoniphilus spp.

Peptostreptococcus spp.

Veillonella parvula

Other microorganisms

treponema pallidum

Indication
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Dosage and method of use
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One hour before meals:
  • Adults and children over 12 years: 1,5-8 mio IU/day p.o. in 3 ED.
  • Children 6-12 years: 40-60.000 IU/kg KG 3 times/day p.o.
  • Children 1-5 years: 15-20.000 IU/kg KG 3 times/day.
  • Infants: 15-20.000 IU/kg KG 3 times/day.

Preparations
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Isocillin, Megacillin, Jenacillin V

Note(s)
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With proven sensitivity, penicillin V has a 10 to 100 times stronger effect against staphylococci than staphylococci penicillins.

Due to its acid stability, phenoxymethylpenicillin is absorbed in the upper sections of the small intestine after largely loss-free passage through the stomach. The resorption rate is about 60%. The extent of absorption also depends on the galenic form. Solid dosage forms are less problematic than granulates for the preparation of a solution/suspension.

1 mg phenoxymethylpenicillin corresponds to 1695 I.U.

Literature
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  1. Wright GD (2007) Biochemistry. A new target for antibiotic development. Science 315: 1373-1374
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Last updated on: 29.10.2020