Pachyonychia L60.2

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 25.01.2023

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Nail thickening; Onychauxis; Pachyonychia; Pachyonyxia; Scleronychia

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Congenital or acquired thickening and hardening of the nail plate (gr.: pachys= thick), possibly with enlargement and deformation(onychogrypose) as a result of increased and disturbed nail growth.

As a single term for a nail condition the term is not very common. In connection with the congenital "Pachyonychia congenita" it is the eponym. S. a. Scleronychia.

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The symptom Pachyonychia or Onychauxis occurs reactively as an isolated symptom in the following diseases or influences on the skin:

  • as a consequence of trauma
  • in case of frostbite
  • by strong pressure effects on the nail, e.g. by too tight shoes
  • in acromegaly
  • in Darier's disease
  • in psoriasis
  • in pityriasis rubra pilaris

Furthermore, the symptom is observed hereditarily associatively in syndromes e.g. in pachyonychia congenita or in combination with diffuse alopecia (Nikoo A 2012).

It has also been described as a non-syndromic autosomal recessive nail dysplasia (syn: Claw-Shaped Nails, NDNC10) due to a mutation in the FZD6 gene (gene locus 8q22.3).

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  1. Nikoo A (2012) Pachyonychia congenita-associated alopecia. Case Rep Pathol 2012:850658.

Outgoing links (2)

Onychogrypose; Scleronychia;


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 25.01.2023