Neutrophilic panniculitis M79.3

Polyätiological panniculitis in existing myelodysplastic syndrome or rheumatoid arthritis; also occurring as ADR in therapy with BRAF inhibitors, e.g. vemurafenib.

Furthermore, the syndrome has been observed in autoinflammatory syndromes such as Sweet's syndrome and Crohn's disease as well as in hereditary alpha-1-antitrypsin deficiency.

Painful nodules and plates in the subcutis with red, overlying skin.

Signs of inflammation with elevation of ESR and CRP, leukocytosis and neutrophilia (possibly hematological signs of myelodysplastic syndrome see there).

Treatment of the underlying disease. Rapid response to systemic glucocorticoids. Symptomatic local therapy. Reduction of therapy with BRAF inhibitors.

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