Leser-Trélat syndrome L82

Edmund Leser and Ulyssee Trélat, 1890; Dutchman, 1900

Very rare (controversial) paraneoplastic syndrome, characterized by multiple, eruptive-exanthematic, usually intensely itchy verrucae seborrhoicae on non-inflammatory skin.

In about half of the cases, the syndrome is associated with acanthosis nigricans maligna (questionable special form). Occurs mainly in adenocarcinomas of the gastrointestinal tract, less frequently in lymphomas (e.g. in mycosis fungoides/Şanlı H et al. 2025)

The joint occurrence of seborrhoeic keratoses and malignancies is not an unusual feature due to the age disposition of both diseases. As reader-Trélat syndrome this clinical constellation can only be addressed if the verrucous changes (possibly +acanthosis nigricans) suddenly appear eruptively.

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11. Şanlı H et al (2025) Seborrheic keratosis-like mycosis fungoides: A rare variant with clinical, dermatoscopic, and dermatopathological features. J Dtsch Dermatol Ges 23:108-110.

12. Schmidt MF et al. (2021) Hyperplasia-associated obligate paraneoplasia of the skin Hautarzt 72:295-298.

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