Interferon beta-1a

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

beta-interferon-1a; IFN β-1a; IFN-β-1a; interferon-beta-1a; Interferon-β-1a; β-Interferon-1a

Definition
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Indication
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Multiple sclerosis characterized by 2 or more relapses within the last 2 years.

Limited indication
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Severe kidney and liver damage, severe myelosuppression.

Pregnancy/nursing period
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Contraindicated.

Dosage and method of use
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  • S.c. (Rebif): inject 44 µg of solution 3 times/week if higher dose is not tolerated Reduction to 22 µg s.c. 3 times/week
  • I.m. (Avonex): 1 time/week 30 µg i.m.

Undesirable effects
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Frequently flu-like general symptoms (fever, fatigue, chills, headaches, myalgia, sweating), reactions at the injection site (erythema)

Contraindication
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Severe depression, suicidal tendency, epilepsy with seizures that cannot be sufficiently controlled therapeutically, Pat. < 16 LJ.

Preparations
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Avonex, Rebif

Note(s)
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Remember! No use together with other immunomodulators except glucocorticoids or ACTH. Caution is advised in case of comedication with substances which are primarily metabolised by the cytochrome P450 system (e.g. antiepileptic drugs).

Outgoing links (2)

Cytokines; Interferon beta;

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Last updated on: 29.10.2020