HistoryThis section has been translated automatically.
Heck, 1963; Archard, Heck and Stanley, 1965
DefinitionThis section has been translated automatically.
Rare warty, mucosa-coloured papules and plaques of the oral mucosa caused by human papilloma viruses ( HPV types 13 and 32; rare detection of HPV types 1, 6, 11). The disease is commonly found in Eskimos and the Indian population in South America. In children: comorbidity with HIV infection is known.
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Occurrence/EpidemiologyThis section has been translated automatically.
Especially Indians and South Americans, Asians. Less so among Europeans. Occasionally a family cluster has also been described.
EtiopathogenesisThis section has been translated automatically.
In larger studies > 85% of patients were HPV positive. HPV32 was detected in 50%, HPV6 in 30% and HPV40 in 5%. HPV32 but not HPV6 was detected in HIV infected patients.
ManifestationThis section has been translated automatically.
LocalizationThis section has been translated automatically.
Oral mucosa; mainly lip red (here on the mucosal side of the lower lip); corner of the mouth; cheek mucosa (about 65 % of patients); more rarely the floor of the mouth or the palate is affected.
Clinical featuresThis section has been translated automatically.
Multiple wart-like, oral mucosa-coloured to whitish, persistent over months and years, broadly seated on the base, soft papules with a tendency to confluence. Size: 0,5-1,0 cm. Aggregation of the growths may result in larger, humpy beds.
HistologyThis section has been translated automatically.
TherapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Archard HO, Heck JW, Stanley HR (1965) Focal epithelial hyperplasia: an unusual and mucosal lesion found in Indian children. Oral Surg Oral Med Oral Catholic 20: 201-212
- Feller L et al (2010) Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. SADJ 65:172-175Gökahmetoğlu
S et al(2015)Focal epithelial hyperplasia in a Turkish family. Infez Med 22:322-325
- Khanal S et al (2016) Human papillomavirus detection in histologic samples of multifocal epithelial hyperplasia
: a novel demographic presentation.
Oral Surg Oral Med Oral Pathol 120:733-743.
- Kose O et al (2001) Focal epithelial hyperplasia treated with interferon alpha-2a. J Dermatologist Treat 12: 111-113
- Knoth W et al (1978) Hyperplasia multilocularis mucosae oris HECK (Sog. Focal epithelial hyperplasia). Z Hautkr 53: 675-679
- Nartey NO et al (2002) Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. J Clin Pediatr Dent 27: 63-66
- Sabeena S et al (2016) Papilloma of lip associated with human papilloma viruses-32 infection in a child. Indian J Med Microbiol 34:97-99
- Syrjanen S (2003) Human papillomavirus infections and oral tumors. Med Microbiol Immunol (Berl) 192: 123-128
- Witkop CJ Jr, Niswander JD (1965) Focal epithelial hyperplasia in Central and South American Indians and Latinos. Oral Surg Oral Med Oral Catholic 20: 213-217
Incoming links (7)Focal epithelial hyperplasia; Heck, m.; Heck's disease; Hyperplasia multilocularis mucosae oris heck; Mucosal warts; Papillomatosis floride oral; Papillomavirus;
Outgoing links (7)Acanthosis; Cauterization; Curettage; Excision; Papel; Papillomatosis; Papillomavirus;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.