Synonym(s)
angioplasia papulosa; Kimura disease; Papular angioplasia; subcutaneous angiolymphoid hyperplasia with eosinophilia (Wells und Whimster)
HistoryThis section has been translated automatically.
Kim and Szeto 1937; Kimura, 1948; Wells and Whimster, 1969
DefinitionThis section has been translated automatically.
Multicentric, benign lymphoproliferative hyperplasia, clinically characterized by dermal nodules and nodules, but also by subcutaneous nodules with edema, lymphocytic and eosinophilic infiltrates, formation of germinal centres, fibrosis and hyperplasia of blood vessels. Some authors make a distinction between Kimura disease and angiolymphoid hyperplasia with eosinophilia based on clinical and histological criteria. Apparently, overlaps of both clinical pictures are observed.
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Occurrence/EpidemiologyThis section has been translated automatically.
Panethnic among men and women of all ages. Unlike M. Kimura no preference of the Asian population.
EtiopathogenesisThis section has been translated automatically.
Unknown.
LocalizationThis section has been translated automatically.
No predilection sites; in Kimura M. the scalp and neck region are preferentially affected.
Clinical featuresThis section has been translated automatically.
Single or multiple, 2-40 mm in size, hemispherical, red to reddish-brownish, more rarely purple or ulcerated nodules and nodes. Rarely disseminated occurrence or lymphadenopathy. Very severe pruritus (missing in Kimura disease!). In Kimura M. larger subcutaneous (also intramuscular) non-itching nodules are observed.
HistologyThis section has been translated automatically.
Dermal and subcutaneous diffuse infiltrate of T and B lymphocytes and eosinophils. Moderate fibrosis, slight edema, sporadic formation of germinal centres. Normally structured vessels with numerous, partly solid vascular sprouts of little differentiated cell elements. Occasional mast cells.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
Excision for longer periods of storage. Danger of bleeding! Possibly alsoCO2 laser. Recurrence treatment in patients > 65 years with X-rays (GD: 20-30 Gy). Combinations ofCO2 laser irradiation with intralesional glucocorticoid application such as triamcinolone acetonide crystal suspension (e.g. Volon A diluted 1:3 with a local anaesthetic, e.g. Scandicain) are also described as successful.
Progression/forecastThis section has been translated automatically.
Chronic progressive but benign course.
LiteratureThis section has been translated automatically.
- Asadi AK (2002) Angiolymphoid hyperplasia with eosinophilia. Dermatol Online J 8: 10
- Helander SD et al (1995) Kimura` disease and angiolymphoid hyperplasia: New observations from immunohistochemical studies of lymphocyte markers, endothelial antigens, and granulocyte proteins. J cutan pathol 22: 319-326
- Kempf W et al (2002) Angiolymphoid hyperplasia with eosinophilia: evidence for a T-cell lymphoproliferative origin. Hum Pathol 33: 1023-1029
- Kim HT, Szeto C (1937) Eosinophilic hyperplastic lymphogranuloma, comparison with Mikulicz`s disease. Chin Med J 23: 699
- Kimura T et al (1948) Unusual granulation combined with hyperplastic changes of lymphoid tissue. Trans Soc Pathol Jpn 37: 179
- Krapohl BD et al (2003) A rare vasoproliferative lesion: angiolymphoid hyperplasia with eosinophilia of the hand. Br J Plast Surgery 56: 168-170
- Metze D et al (1991) Angiolymphoid hyperplasia with eosinophilia (AHE). Dermatologist 42: 101-106
- Schirren CG et al (1991) Angiolymphoid hyperplasia with eosinophils. Dermatologist 42: 107-111
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Incoming links (3)
Angioplasia, papular; Kimura disease; Subcutaneous angiolymphoid hyperplasia with eosinophilia;Outgoing links (14)
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Prof. Dr. med. Peter Altmeyer