Hydroquinone

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Hydroquinones (INCI); Hydroquinones (INCI-Kennzeichnung)

Definition
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Depigmentation agent.

Pharmacodynamics (Effect)
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Inhibition of tyrosinase and oxidative phosphorylation and thus of melanin synthesis; existing pigment is not destroyed.

Indication
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Ephelides, lentigines, Chloasma.

Dosage and method of use
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Apply thinly to the changed skin once/day. Treatment duration 6-12 weeks. Stop treatment if no skin lightening occurs after 3 months at the latest.

Standard concentration
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2-3% in ointments and creams. There is no prescription obligation; a concentration limit of up to 3% is recommended.

Remember! Controversial therapy principle, perform epicutaneous test before use! Negative monograph!

Important: A combination preparation is preferable to monotherapy.

Undesirable effects
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Allergic reactions, permanent depigmentation, danger of inducing vitiligo (especially in dark-skinned people).

Incompatibility
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Alkaline reacting substances, oxidizing agents, iron and heavy metal salts.

Recipe(s)
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See also the depigmenting 3% hydroquinone ointment.

Preparations
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Finished preparations are available with the 5% hydroquinone cream Pigmanorm® (Widmer).

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Last updated on: 29.10.2020