Herxheimer reaction T78.2

Author: Prof. Dr. med. Peter Altmeyer

Our authors

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

Jarisch-Herxheimer reaction; Reaction Jarisch-Herxheimer

History
This section has been translated automatically.

Jarisch, 1895; Herxheimer, 1902

Definition
This section has been translated automatically.

At the beginning of a therapy due to massive pathogen decay, a reaction with fever, chills, general reactions, e.g. with syphilis. With appropriate therapy, a similar reaction can also occur with tinea capitis profunda, tinea corporis profunda and onchocerciasis.

Etiopathogenesis
This section has been translated automatically.

Rapid disintegration of spirochetes or fungi with release of toxins after the first administration of antibiotics or antifungals.

Clinical features
This section has been translated automatically.

For syphilis: 2-6 hours after the first administration of penicillin, with feverish temperatures, flu-like symptoms, arthralgia, chills, headaches. In the rare late stage with an existing aortic aneurysm life-threatening (possible aortic aneurysm rupture due to sudden disintegration of the granulation tissue). No recurrence occurs with the following injections.

Prophylaxis
This section has been translated automatically.

Simultaneous administration of 25-50 mg prednisolone i.v. one hour before or with the initial administration of antibiotics.

Note(s)
This section has been translated automatically.

Literature
This section has been translated automatically.

  1. Herxheimer K (1902) On a mercury reaction occurring in syphilitic patients. German medical weekly (Berlin) 28: 895-897
  2. Jarisch A (1895) Therapeutic trials for syphilis. Viennese medical weekly 45: 720-721
  3. Leblebicioglu H (2003) Jarisch-herxheimer reaction in leptospirosis. Eur J Clin Microbiol Infect Dis 22: 639
  4. Silberstein P (2002) A case of neurosyphilis with a florid Jarisch-Herxheimer reaction. J Clin Neurosci 9: 689-690

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Authors

Last updated on: 29.10.2020