Herpespsis of the newborns B00.7
Synonym(s)
Herpes-Sepsis of the newborns
Definition
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Severe, generalized initial infection with Herpes simplex virus(in 75% of cases Herpes simplex type 2), in the newborn (see also Herpes neonatorum).
Etiopathogenesis
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Infection during the passage of the birth canal when the mother is ill. Rarely infection by sick nursing staff.
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Manifestation
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Especially for premature babies.
Clinic
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Incubation period 3-6 days. Generalized vesicle eruption, aphthous changes in the mucous membranes, high fever, keratoconjunctivitis. Icterus, dyspnoea, swelling of liver and spleen, tendency to bleed, meningismus or meningoencephalitis.
Differential diagnosis
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Internal therapy
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Gamma globulins (e.g. beriglobin 0,2-0,5 ml/kg bw/day i.v.). Aciclovir (strictest indication in infancy) 3 times/day as short infusion (dosage: 380 mg/m2 KO/day).
- Ante partum: Gamma globulin injection in the mother (e.g. beriglobin 20 ml i.m.).
- Post partum: Gamma-globulin injection in the child (e.g. pentaglobin 3-5 ml i.v. on three consecutive days).
Progression/forecast
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In 60% of cases death within the first week, in another 20% permanent disorders.
Prophylaxis
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Abdominal incisional ligation in case of maternal disease.
Recommended articles
Incoming links (1)
Sepsis skin changes;Outgoing links (4)
Aciclovir; Folliculitis (overview); Herpes simplex virus infections; Impetigo (overview);Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
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Prof. Dr. med. Peter Altmeyer