Granuloma anulare multiforme L92.8

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

Granuloma anulare multiforme; Granuloma multiforme; Mkar disease; Mkar Disease; Nkanu disease

History
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Leiker, 1964

Definition
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A chronic, granulomatous skin disease of unknown etiology, frequently occurring in Central Africa. Possibly identical with actinic granuloma.

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Occurrence/Epidemiology
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Especially in Central and East Africa.

Manifestation
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Mostly adults, gynecotropia.

Localization
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Mainly arms and hands, upper torso, head.

Clinic
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Rough skin-colored papules confluent to polycyclic foci with central healing and depigmentation. Initial itching, otherwise without symptoms.

Histology
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Circumscribed necrobiosis foci in the corium with peripheral histiocytic border wall and numerous giant cells.

Differential diagnosis
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Leprosy, granuloma anulare; sarcoidosis; tuberculosis cutis luposa; granulomatosis disciformis chronica et progressiva.

Therapy
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No useful therapy modalities are known.

Progression/forecast
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Eminently chronic disease with a course lasting months to years. Spontaneous healing after years is described.

Literature
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  1. Garrett AS (1999) Granuloma multiforme (called Nkanu disease in the 1940s and Mkar disease in 1964) Int J Lepr Other Mycobact Dis 67: 172-174
  2. Krampitz HE (1967) Granuloma multiforme Leiker. dermatologist 18: 365-368
  3. Leiker DL et al (1964) Granuloma multiforme. A new disease resembling leprosy. Int J Lepr 32: 368-370.
  4. Rogge T (1977) Granuloma multiforme. Dermatologist 28: 375-377

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Incoming links (3)

Granuloma actinic; Granuloma multiforme; Mkar disease;

Outgoing links (8)

Granuloma actinic; Granuloma anulare classic type; Granulomatosis disciformis chronica et progressiva; Leprosy (overview); Papel; Pruritus; Sarcoidosis of the skin; Tuberculosis cutis luposa;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer Prof. Dr. med. Peter Altmeyer

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