DefinitionThis section has been translated automatically.
Frequent, harmless, epithelium-coated cavities of varying size, usually skin-coloured, 1.0 - 3.0 cm, located in the middle or deep dermis, with gelatinous or solid contents, of varying genesis (traumatic, inflammatory, genetic).
ClassificationThis section has been translated automatically.
A distinction is made according to the shutter release:
- Primary epidermal cyst: Etiologically unexplained.
- Secondary epidermal cyst: Traumatically induced.
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EtiopathogenesisThis section has been translated automatically.
In most cases retentions resulting from obstruction of the follicleostium, which secondarily lead to proliferation of the follicular epithelium. Multiple epidermal cysts on the trunk usually occur in connection with an acne vulgaris or conglobata. The etiology of the so-called primary epidermal cysts is unclear.
ManifestationThis section has been translated automatically.
Teenagers, young and middle-aged adults,
LocalizationThis section has been translated automatically.
Ubiquitous; mainly affects face, trunk, proximal extremity and rarely soles of feet
Clinical featuresThis section has been translated automatically.
- Solitary or plural, indolent, deeply dermal, easily delimited, 0.2 to 3.0-5.0 cm large, skin-coloured, only rarely pigmented, plumply elastic tumour which slides on the base. Clinically and dermatoscopically a central porus is usually detectable. Rupture and consecutive acute abscess formation(boils) possible.
- In the case of multiple epidermal cysts, the medical history usually shows acne vulgaris or acne conglobata.
- Multiple epidermal cysts characterize the so-called sebocystomatosis scroti.
- Multiple cysts can be a partial symptom of a Gardner syndrome or basal cell nevus syndrome.
- Multiple epidermal cysts have also been observed in isolated cases after immunosuppressive treatment of organ transplanted patients with Ciclosporin A.
HistologyThis section has been translated automatically.
The cyst wall consists of layered squamous epithelium with formation of a stratum granulosum. In the lumen there are stratified horny lamellae like onion shells and more or less hairs depending on the age of the cyst. In case of rupture, dense granulomatous infiltrate with giant cells of foreign body type is found in the cyst lumen and in the surrounding area.
Differential diagnosisThis section has been translated automatically.
Complication(s)This section has been translated automatically.
TherapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Basterzi Y et al (2002) Giant epidermoid cyst on the forefoot. Dermatol Surgery 28: 639-640
- Cameron DS et al (2003) Squamous cell carcinoma in an epidermal inclusion cyst: case report. Otolaryngol Head Neck Surgery 129: 141-143
- El Alami M et al (2003) Laser marsupialization of epidermal cysts: avoiding linear scars. J Clin Laser Med Surg 21: 161-163
Ghigliotti G et al (2014) Usefulness of dermoscopy for the diagnosis of epidermal cyst: the 'pore' sign. Clin Exp Dermatol 39:649-650
- Gupta S et al (2000) Multiple, large, polypoid infundibular (epidermoid) cysts in a cyclosporin-treated renal transplant recipient. Dermatology 201: 78
- Ishida M et al (2014) Epidermal cyst of the skin with ossification: report of two cases. Int J Clin Exp Pathol 7:1823-1825
- Lee S et al (2003) Detection of human papillomavirus 60 in epidermal cysts of nonpalmoplantar location. At J Dermatopathol 25: 243-247
- Morgan MB et al (2001) Carcinoma arising in epidermoid cyst: a case series and aetiological investigation of human papillomavirus. Br J Dermatol 145: 505-506
- Shet T, Desai S (2001) Pigmented epidermal cysts. At J Dermatopathol 23: 477-481
- Tsuruta D et al (2000) Combined cutaneous hamartoma encompassing benign melanocytic naevus, vellus hair cyst and epidermoid cyst. Clin Exp Dermatol 25: 38-40
Incoming links (21)Atheroma; Boils; Cyst; Cyst, epidermal; Cyst, infundibular; Epidermal cysts; Epidermal cysts, traumatic; Epidermoid cysts; Epidermoid cyst, subungual; Epithelial cysts, traumatic; ... Show all
Outgoing links (9)Acne conglobata; Acne (overview); Basal cell nevus syndrome; Boils; Ciclosporin a; Epidermal cysts on scrotum and vulva; Gardner syndrome; Local anesthesia; Trichilemmal cyst;
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