Eosinophilic ulcer of the oral mucosa K12.1

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

eosinophilic ulcer; Eosinophilic ulcer of the tongue; Oral eosinophilic ulcer; Oral eosinophilic ulcers; Ulcer eosinophils of the oral mucosa

Definition
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The eosinophilic ulcer of the oral mucosa is a rare, benign, painful, self-limited lesion (rarely a recurrent course) of unknown etiology, usually lasting several weeks (months).

Etiopathogenesis
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Unknown, traumatic (Sah K et al. 2017)?

Manifestation
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Any age; advanced adulthood is preferred; no sex predilection.

Localization
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Oral mucosa, preferably on the tongue

Clinical features
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Initially circumscribed nodular infiltrate, early ulceration. A solid, greasy, painful, 0.5-2.0 cm ulcer with prominent, firm margins persists (Lingaraju N et al. 2015).

Histology
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Ulcer extending to the submucosa and the musculature with mixed-cell inflammatory infiltrate with prominent eosinophilia. No cell atypia observed. The determination of CD30+ cells is important for the differential diagnostic differentiation from the lymphomatoid papulose of the oral mucosa.

Differential diagnosis
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Squamous cell carcinoma, lymphoma of the oral mucosa; an etiopathogenetic relationship to the (rare) form of the oral lymphomatoid papulose is unclear (Schwartz Z et al. 2017).

Progression/forecast
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Characteristic is the limited course of 1-5 months, whereby the ulcer can heal spontaneously after probiotic biopsy.

Sugaya N et al. described a recurrent course over a period of 2.5 years.

Typical is the therapy resistance to the usual topical agents.

Literature
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  1. Didona D et al (2015) Eosinophilic ulcer of the tongue--Case report. An Bras Dermatol 90(3 Suppl 1):88-90.
  2. Lingaraju N et al. (2015) Eosinophilic ulcer of the tongue: a rare and confusing clinical entity. BMJ Case Rep pii: bcr2015210107
  3. Sah K et al (2017) Eosinophilic ulcer of the tongue masquerading as malignant ulcer: An unexplored distinct pathology. J Oral Maxillofac Pathol 21:321.
  4. Schwartz Z et al (2017) Oral lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma. Ann Diagn Pathol 31:50-55.
  5. Sugaya N et al (2018) Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report. Open Dent J 12:19-23.

Incoming links (1)

Lymphomatoids papulose;

Outgoing links (1)

Lymphomatoids papulose;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020