Econazole

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Topical imidazole antifungal.

Pharmacodynamics (Effect)
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Inhibition of the synthesis of steroidal membrane components with subsequent permeability disturbance and lysis of the cells of dermatophytes, yeasts and moulds.

Indication
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Skin infections caused by fungi and gram-positive bacteria.

Dosage and method of use
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  • Apply 1% as cream, lotio, solution 2 times/day for 2-4 weeks thinly on the affected skin areas.
  • In case of pityriasis versicolor, additionally apply sachet of 100 mg on 3 consecutive days in the evening after showering (do not dry off), massage into scalp and body for 3-5 minutes, allow to dry and rinse off the following day.
  • In the case of mycotic balanitis, cream glans penis twice a day and place a strip of gauze soaked in cream under the prepuce (partner treatment!).
  • Candida vulvovaginitis (partner treatment!): 3 days in the evening one vaginal tablet of 150 mg each or 6 days in the evening one vaginal tablet of 50 mg each or an applicator filling of cream.

Undesirable effects
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Allergic reactions including anaphylactic shock, erythema, burning of the skin, photosensitization, edema.

Contraindication
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Pregnancy, first trimester, azole hypersensitivity.

Preparations
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Epi-Pevaryl, Gyno-Pevaryl

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Last updated on: 29.10.2020