Doxepin

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Antidepressant.

Indication
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Depressive syndromes, regardless of their nosological classification; anxiety syndromes; mild withdrawal syndromes in cases of alcohol, drug or medicine addiction; restlessness, anxiety, sleep disorders and functional organ problems.

Dosage and method of use
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Gradual dosage at the beginning and gradual discontinuation at the end of the treatment. Start with 10-25 mg, depending on the severity of the disease, gradual increase to max. 75-150 mg doxepin in outpatient therapy. In patients over 60 years of age about half of the recommended dose is usually sufficient. Up to 100 mg can be administered as a single dose in the evening 2-3 hours before bedtime.

Undesirable effects
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Among others, exanthema, hyperhidrosis, hair loss, dry mouth, salivation, difficulty swallowing, gastrointestinal disorders, cardiac arrhythmia, gynecomastia, loss of libido, syndrome of inadequate ADH secretion.

Interactions
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The antihypertensive effect of nitrates and antihypertensive drugs can be enhanced, the effect of reserpine can be weakened.

Contraindication
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Allergy to doxepin, urinary retention, paralytic ileus, narrow-angle glaucoma, MAO inhibitors, delirium, childhood.

Preparations
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Aponal, Sinquan

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Last updated on: 29.10.2020