Dequalinium chloride (inci)

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Dequalinium chloride

Definition
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Cationic antiseptic from the group of quaternary ammonium bases. The molecule also has quinoline structures. Disinfection not undisputed in local application. Time and again mucosal necrosis has been reported when applied.

Pharmacodynamics (Effect)
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Antibacterial and fungicidal effect through protein precipitation.

Indication
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Infections of the mucous membranes, superficial skin infections.

Notice! Doubtful therapeutic principle, the therapeutic benefit is not sufficiently proven!

Dosage and method of use
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  • Ointments/creams: Apply thinly 1-3 times/day.
  • Vaginal tablets: In the case of fluoride vaginalis, insert deep into the vagina in the evening for 4-6 days.

Standard concentration
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0.4% in ointments and creams, 2% vaginal tablets.

Undesirable effects
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In combination with top. Glucocorticoids under occlusive conditions danger of skin irritation up to necrosis formation (for applications in the preputial area - here danger of concentration potentiation).

Contraindication
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Hypersensitivity to the active substance; use in the preputial area (risk of necrosis).

Incompatibility
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Soaps, anion-active emulsifiers, phenol, chlorocresol.

Recipe(s)
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Preparations
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Fluomycin, Maltyl gargle, Sorot, Evazol cream

Literature
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  1. Wolf G (2007) recipe tip. dermatologist 58: 476-477

Authors

Last updated on: 29.10.2020