DefinitionThis section has been translated automatically.
Depigmentation is a pathological, clinical symptom caused by a congenital or acquired, solitary or multiple, localized or disseminated, in rare cases also generalized or universal color loss of the skin, caused by a melanin deficiency(hypomelanosis) or by a complete melanin loss(amelanosis) of the skin due to loss or dysfunction of melanocytes. If depigmentation or hypopigmentation occurs temporarily as a result of skin diseases (intra- and/or perilesional), they are called leukoderms, s.a. pseudoleukoderm.
Depigmentation is the opposite pathological finding of hyperpigmentation.
ClassificationThis section has been translated automatically.
In the following, clinical pictures are listed which are characterized by the clinical symptom "depigmentation".
- Congenital depigmentation:
- Incontinentia pigmenti achromians = Ito-Syndrome (depigmentation in striped arrangement = Blaschko line pattern)
- Naevus depigmentosus (mostly localized depigmentation)
- Albinism (mostly generalized or universal depigmentation)
- Albinoidism, oculocutaneous (minus variant of albinism)
- Piebaldism (partial albinism, white forelock)
- Pringle-Bourneville phacomatosis (ash leaves - depigmentation)
- Phenylketonuria (diffuse hypopigmentation)
- Poliosis (white forelock)
- Waardenburg Syndrome
- Tietz Syndrome
- Hermansky-Pudlak syndrome
- Chédiak-Higashi syndrome (minus variant of oculocutaneous albinoidism)
- Griscelli syndrome (diffuse hypopigmentation)
- Elejalde syndrome (partial albinism).
- Acquired depigmentation:
- Depigmented pseudo scars
- hypomelanosis guttata idiopathica
- Progessive macular hypomelanosis (caused by P. acnes)
- Print depigmentation (contact surfaces in the solarium)
- Koala Bear Syndrome (Chronic Fatigue Syndrome)
- Postinflammatory depigmentations
- By the action of chemical noxae (monobenzylether, hydroquinone, benzoyl peroxide, paraternary butylphenol -4-TBP; other phenol derivatives)
- Drug-induced: phenol derivatives (in bleaching creams), benzoyl peroxide, azelaic acid, retinoids, parenteral glucocorticoids; topical imiquimod, diphencylcopropenone, interferon-alpha, interleukin-2, chloroquine, hydroxychloroquine)
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EtiopathogenesisThis section has been translated automatically.
- Change in melanocyte count
- inadequate melanin synthesis
- defects in the maturation, transport or transfer of melanosomes
Note(s)This section has been translated automatically.
The opposite finding, the pathological compression of the melanin of the skin or mucous membrane, is called hyperpigmentation.
LiteratureThis section has been translated automatically.
- Giehl K et al (2010) Genetically caused pigmentation disorders. Dermatologist 61: 567-577
Incoming links (17)Achromia parasitica; Amelanose; Camouflage; Hypomelanosis; Hypomelanosis ito; Leucoderm; Lupus erythematodes chronicus discoides; Melanin; Pigment; Pigmentation; ... Show all
Outgoing links (40)Albinism (overview); Albinoidism, oculocutaneous; Amelanose; Azelaic acid; Benzoyl peroxide; Chediak higashi syndrome; Depigmented nevus; Diphenylcyclopropenone (dpcp); Elejalde syndrome; Glucocorticosteroids systemic; ... Show all
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.