DefinitionThis section has been translated automatically.
Dominant cytoskeletal proteins of epithelial cells, which represent the most important part of the cytoskeleton. Cytokeratins (= alpha-keratins; see below keratins) are cytoplasmically localized and belong to the group of intermediate filaments. They can also be expressed in non.epithelial tumors, e.g. leiomyosarcoma, epithelioid angiosarcoma, epithelioid fibrosarcoma. Possible co-expression with other intermediary filaments (e.g. vimentin). Cytokeratins have, among other things, a high diagnostic importance (see CK7, CCK10, CK20 and others) in determining the histogenesis of tumours.
General informationThis section has been translated automatically.
More than 20 different cytokeratins (CK/ZK) are known. They are classified according to their chemical properties into acidic (TYPE A) or neutral-basic cytokeratins (TYPE B) or according to their molecular weight into high and low molecular cytokeratins. There are a number of antibodies with specificity for individual cytokeratins, several cytokeratins or cytokeratin groups. In the cytoskeleton, a type A-ZK forms a complex with a type B-ZK, so that epithelia always express at least 2 cytokeratins. Antibodies such as KL-1 or MNF-116 are suitable as markers for pancytokeratin, but also the mixture of two antibodies against acidic and basic cytokeratins AE1/AE3.