Creams ambiphile (overview)

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Ambiphilic creams; Mixed emulsion ointments

Definition
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Creams that represent a transition between hydrophobic creams and hydrophilic creams. They have a bicoherent structure of hydrophilic and lipophilic phase and contain relatively high amounts of oil-in-water emulsifiers as well as water-in-oil emulsifiers. Without breaking the emulsion system, larger quantities of water as well as lipophilic substances can be incorporated, whereby an O/W or W/O emulsion system is formed with sliding transitions. They are almost universally applicable in the formulation.

Pharmacodynamics (Effect)
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The lipid supply is greater for the skin than with O/W emulsion ointments, but like these they are easy to spread and wash off and have a certain cooling effect.

Indication
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Subacute skin diseases in seborrhoeic and sebostatic skin types.

Incompatibility
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  • In ambiphilic creams containing non-ionic emulsifiers with a hydrophilic polyethylene glycol portion, the incorporation of phenolic substances may lead to a loss of efficacy or even to the breaking of the emulsion depending on their concentration.
  • Inhomogeneities can be caused by active substances such as benzalkonium chloride, benzyl alcohol, cetylpyridinium chloride, chlorocresol, hexachlorophene, β-naphthol, nipagine, oleum thyme, phenol. liquefact., Pix betulin., Pix juniper., Pix lithanth., polidocanol, pyrogallol, resorcinol, salicylic acid, tannin, tetracaine HCl and tyrothricin.
  • Colour changes can be caused by dithranol, oxytetracycline-HCl, silver nitrate and tetracycline-HCl.
  • Chloramine T leads to an odour change.

Tables
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Compatibility of drugs in ambiphilous creams

Acridine flavinium chloride 2%

Dexpanthenol 5%

Sodium chloride 10

allantoin 0,5%

Dimetine maleate 1%

neomycin sulfate 0,5%.

aluminium chloride 10%

Dimeticone 10%

Nicotinic acid benzyl ester 3%.

Ammonium bituminosulphonate 10

Diphenhydramine HCl 2%

nitrofurazone 0,2%

Amphotericin B 3%

Erythromycin 2%

Nystatin 100 000 IU/g

anthrarobin 2%

Ethacridine lactate 1%

Oleum Pini 1,5

azulene 0,2%

Eucalyptol 10%

Pheniramine hydrogen maleate 1,25%

bacitracin 500 IU/g

Gentamicin sulphate 0,2

Polyvidon iodine 10%

Bamipine HCl 2%

Urea 10% Urea

Procaine HCl 2%

Benzoic acid 5%

Hydrarg. sulf. rubr. 1%

Sulphur 5%

Benzoyl peroxide 5%

hydrocortisone 1%

Sorbic acid 0,1% of

betamethasone-17-valerate 0,1%

hydroxyquinoline sulfate 0,5%.

Sulphadiazine 5%

Bufexamac 5%

potassium iodide 3,5%.

sulfisomidine 5%

calcium chloride 5%

Camphor 5%

terpiniol 1,5

Chloramphenicol 1%

Cod liver oil 10%

Tinctura Myrrh 3%

Chlorophenoxamine-HCl 1,5% Chlorophenoxamine-HCl 1,5% Chlorophenoxamine

Liq. alum. acet. 20%

tretinoin 0.1%

Chlortetracycline HCl 3%

Liq. carb. deterg. 10%

triamcinolone acetonide 0,1

Chrysarobin 5%

Menthol 5%

Undecylenic acid 5%

Clioquinol 5%

Merbromine 2%

Zinc oxide 10

clotrimazole 1%

Methyl salicylate 5%

Zinc undecylenate 5%

dexamethasone 0,1%

Lactic acid 5

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Last updated on: 29.10.2020