Clioquinol

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 19.09.2023

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Synonym(s)

Clioquinol Cream 05-2%; Clioquinol hydrocortisone 05% cream; Clioquinol hydrocortisone 1% cream; Clioquinol lotio 05%; Clioquinol zinc paste soft; Shaking mixture Clioquinol containing 05-2

Definition
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Quinoline derivative (5-chloro-7-iodo-8-quinolinol) widely used as an antiseptic and chemotherapeutic agent with antibacterial and fungicidal activity. Strong effect on Entamoeba histolyticum.
Antiseptic, see also dyes.

Indication
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Topical for skin infections.

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Dosage and method of use
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Topical: Apply 2 times/day to the affected areas of skin.

Systemic: Oral 3x 0.25g/day, max. application time 4 weeks. Cave: Side effects with longer use (especially in the Japanese population (Smon disease

Standard concentration
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2-10% in creams, ointments (e.g. 2% clioquinol cream - Rp: clioquinol cream 0.5-2%; also in combinations with flumetasone pivalate), shaking mixtures and as pure substance in powders.

Notice. Stains skin, clothing and objects yellow!

Undesirable effects
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In case of systemic application: SMON disease (Subacute Myelo-Optico Neuropathy; nerve disease that can lead to blindness, used to occur only in Japan).

Incompatibility
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Alkaline reacting substances, iron salts, zinc oxide (discoloration); strongly oxidizing substances (decomposition).

Recipe(s)
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Preparations
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Linola-Sept, vioform,

Literature
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  1. Konagaya M (2015) SMON: toxicity of clioquinol and the status quo. Brain nerve 67:49-62
  2. Sulzberger MB et al (1948) Vioform in dermatologic therapy with particular reference to its use in different vehicles. Arch Derm Syph 58:224-230

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Last updated on: 19.09.2023