Ceftazidim

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 30.09.2022

Dieser Artikel auf Deutsch

Definition
This section has been translated automatically.

Broad-spectrum cefalosporin of the 3rd generation.

Half-life
This section has been translated automatically.

1.7-2.1 hrs. (for newborns 6-8 hours).

You might also be interested in

Spectrum of action
This section has been translated automatically.

Aeromonas hydrophila, Citrobacter spp., Clostridium perfringens, Enterobacter spp., E. coli, Hafnia alvei, Haemophilus spp., Klebsiella spp., Moraxella spp., Morganella morganii, Neisseria spp, Pasteurella multocida, Peptostreptococcus spp., Prevotella spp., Proteus spp., Providencia spp., Pseudomonas spp., Salmonella spp., Serratia spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Yersinia enterocolica

Indication
This section has been translated automatically.

Severe, life-threatening respiratory tract, urinary tract, skin, soft tissue, bone and joint infections.

Dosage and method of use
This section has been translated automatically.

  • 3 times/day 1 g or 2 times/day 2 g i.v. (max. 2-3 times/day 3 g).
  • Children: 25-50 mg/kg bw/day

Remember! In patients > 75 years of age only in case of very severe infections daily doses > 3 g/day!

Undesirable effects
This section has been translated automatically.

Anaphylaxis due to cephlosporins:

In a larger study, 6.8 anaphylactic reactions per 100 000 intravenous exposures were demonstrated. The incidence of fatal anaphylaxis from cephalosporin was 0.1 cases per 100 000 exposures (Kang DY, MS et al. 2018).

The following incidences were found for each cephalosporin:

  • Ceftizoxime: 13.0 anaphylaxis per 100 000 exposures).
  • Cefepime, cefotaxime, ceftizoxime, ceftriaxone, cefuroxime: 9.3 anaphylaxis per 100 000 exposures
  • Cefoxitin, cefmetazole, cefminox, and cefotiam: no anaphylactic reactions.

Neurologic UAWs(rare):

A major review (Lacroix L et al (2019) analyzed 511 reports of serious neurologic UAWs between 1987 and 2017. Patients had a mean age of 67.1 years (m:w= 1:1) with a mean creatinine clearance of 32.9 ml / min.These were observed with the following mostly parenterally administered (87.3%) cefalosporins:

  • Cefepime (33.1%)
  • ceftriaxone (29.7%)
  • ceftazidime (19.6%)
  • cefotaxime (9%)
  • cefazolin (2.9%)

The following neurological UAWs were diagnosed: encephalopathy (30.3%),confusional state (19.4%), convulsions (15.1%), myoclonia (9.4%), status epilepticus (9.2%), coma (6.3%), hallucination (4.3%).

Preparations
This section has been translated automatically.

Fortum®

Literature
This section has been translated automatically.

  1. Kang DY, MS et al (2018) Incidence of cephalosporin-induced anaphylaxis and clinical efficacy of screening intradermal tests with cephalosporins: A large multicenter retrospective cohort study. Allergy 73:1833-1841.
  2. Lacroix L et al (2019) Serious central nervous system side effects of cephalosporins: A national analysis of serious reports registered in the French Pharmacovigilance Databas. J Neurol Sci 398:196-201

Outgoing links (1)

Cephalosporins;

Authors

Last updated on: 30.09.2022