CD5

Synonym(s)

Ly-1

Definition
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Acronym for"cluster of differentiation 5". CD5 is a receptor protein, a member of the superfamily of signal transducing, cysteine-rich scavenger receptors (SRCR) class I. CD5 is encoded by the eponymous CD5 gene (CD5 molecule) located on chromosome 11q12.2.

CD5 is used diagnostically as a marker for: mature T cells, T cell lymphomas and thymocytes.

Furthermore, the antibody marks a subunit of B cells (B-CLL, mantle cell lymphoma). CD5-positive diffuse large B-cell lymphomas (CD5+ DLBCL) are associated with poorer survival.

CD5+ DLBCL has a high frequency of p53 overexpression, and CD5 enhances the negative effect of p53 overexpression in DLBCL (Zhao P et al. 2019).

Application: FACS, IHC (P) (G), IF

General information
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Transmembrane protein (67 kDa); CD5 is a ligand for CD72, a protein(lectin) that is expressed on B cells.

Literature
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Hantschke M et al. (2016) Immunohistological techniques. In: L. Cerroni et al. Histopathology of the skin. Springer Verlag Berlin-Heidelberg pp 26-33.
Velasco-de Andrés M et al. (2020) Soluble CD5 and CD6: lymphocytic class I scavenger receptors as immunotherapeutic agents. Cells 9:2589.
Zhao P et al (2019) CD5 expression correlates with inferior survival and enhances the negative effect of p53 overexpression in diffuse large B-cell lymphoma. Hematol Oncol 37:360-367.