Cd34

Acronym for cluster of differentiation 34th CD34 is a marker for: hematopoietic progenitor cells, pluripotent stem cells, capillary endothelial cells, bone marrow stroma cells, acute myeloid and lymphoblastic leukemia/lymphomas.

Structure: transmembrane glycoprotein (110 kDa); Clone: My10

Application: FACS, IHC (P) (G), IF

The highest expressions of CD34 are found on primitive stem cells. They gradually disappear during differentiation and maturation of the precursor cells. About 60% of all acute B-lymphoid leukemias and 40% of acute myeloid leukemias (AML) and up to 5% of acute T-lymphoid leukemias express CD34.

CD 34 is the best marker of dermatofibrosarcoma protuberans. CD34 also marks numerous soft tissue tumors: solitary fibrous tumor, Kaposi's sarcoma, angiosarcoma, neurogenic tumors, spindle cell lipoma, epithelioidal sarcoma.

1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.