Carcinoma spinocellular desmoplastic - Altmeyers Encyclopedia

Synonym(s)

Carcinoma desmoplastic; desmoplastic carcinoma; desmoplastic carcinoma of the skin; Desmoplastic squamous cell carcinoma

Definition
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Rare (about 8%) histological and clinical variant of squamous cell carcinoma of the skin with high metastatic potential and high local recurrence rate (about 25%) even with adequate surgical procedure.

Clinical features
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Clinically indistinguishable from other spinocellular carcinomas.

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Histology
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Fine strands or smaller tumor cell nests with atypical, very polymorphic keratinocytes surrounded by a broad desmoplastic stroma. The tumour tends to infiltrate growth along autochthonous structures such as nerves or vessels.

Therapy
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Generous surgical removal. Micrographic surgery is recommended as well as sentinel lymph node biopsy.

Literature
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Breuninger H et al (1998) Desmoplastic squamous epithelial carcinoma of the skin and lower lip. A morphologic entity with great risk of metastasis and recurrence. dermatologist 49: 104-108
Breuninger H et al (1997) Desmoplastic squamous cell carcinoma of skin and vermilion surface: a highly malignant subtype of skin cancer. Cancer 79: 915-919
Norris CM Jr et al (1986) Desmoplastic squamous cell carcinoma of the tongue simulating myositis or fasciitis. Head neck surgery 9: 51-55
Petter G, Haustein UF (2001) Rare and newly described histological variants of cutaneous squamous epithelial carcinoma. Classification by histopathology, cytomorphology and malignant potential. dermatologist 52: 288-297