Cannabinoids

A sticky, resinous film is secreted on the surface of the plant. This film has an antimicrobial effect and protects the plant from microorganisms (bacteria and fungi). There are both natural and synthetic cannabinoids. Important natural cannabinoids are the psychotropic delta-9-tetrahydrocannabinol (THC), as well as the non-psychotropic cannabinoids cannabidiol (CBD) and cannabinol (CNB).

The cannabinoid receptors CB1 and CB2 are the target structures of the cannabinoids when they are absorbed into the human organism. The receptors bind N-palmitoylethanolamine(PEA) and mediate analgesic, sedative and antiemetic effects.

Nabilone, a synthetic cannabinoid, is used as an antiemetic in oncology.

The expression of cannabinoid receptors in human skin is dermatologically relevant. This knowledge has already been used in studies for the treatment of chronic pruritus (available preparation = Physiogel AI cream).

1. Ständer S et al (2005) Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci 38: 177-188