Cannabinoids

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 20.05.2021

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Definition
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Substances secreted by the hemp plant (cannabis) as resin on the surface of the leaves.

General information
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A sticky, resinous film is secreted on the surface of the plant. This film has an antimicrobial effect and offers the plant protection against microorganisms (bacteria and fungi). There are both natural and synthetic cannabinoids. Important natural cannabinoids are the psychotropic delta-9-tetrahydrocannabinol (THC) and the non-psychotropic cannabinoids cannabidiol (CBD) and cannabinol (CNB).

Target structures of the cannabinoids upon uptake into the human organism are the cannabinoid receptors CB1 and CB2. The receptors bind N-palmitoylethanolamine(PEA) and mediate analgesic, sedative, and antiemetic effects.

Nabilone, a synthetic cannabinoid, is used as an antiemetic in oncology.

Dermatologically relevant is the expression of cannabinoid receptors in human skin. This knowledge has already been applied in studies for the treatment of chronic pruritus (available preparation = Physiogel AI cream).

Note(s)
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Cannabinoids are on the doping list!

Literature
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  1. Ständer S et al (2005) Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci 38: 177-188

Incoming links (2)

Cannabidiol ; Tetrahydrocannabinol;