Bacitracin

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Topical preparation from the group of polypeptide antibiotics from certain strains of Bacillus subtilis and licheniformis.

Pharmacodynamics (Effect)
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Inhibition of the murein synthesis of the bacterial cell wall.

Indication
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Infections with Gram-positive and -negative cocci (spectrum of action similar to that of penicillins).

Dosage and method of use
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Apply locally 2-3 times/day.

Standard concentration
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1%, i.e. 600 IU/g in water absorbing ointments (absorption bases), hydrophilic ointments, ungt. leniens, hydrophilic creams (O/W emulsion ointments), carmellose gel, hydroxyethyl cellulose gel and powders, often combined with neomycin (against gram-negative germs).

Undesirable effects
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Danger of sensitization with frequent use. Occasional contact dermatitis. Rarely anaphlactic reactions have been described with local application.

Preparations
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Polyspectran (combination with polymyxin-B and neomycin), nebacetin (combination with neomycin), bivacyn (combination with neomycin)

Literature
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  1. Cronin H et al (2009) Anaphylactic reaction to bacitracin ointment. Cutis 83:127-129
  2. Fransway AF et al (2013) North American Contact Dermatitis Group patch test results for 2007-2008 Dermatitis 24:10-21
  3. Spring S et al (2012) Contact dermatitis to topical medicaments: a retrospective chart review from the Ottawa Hospital Patch Test Clinic. Dermatitis 23:210-213
  4. Warshaw EM et al (2012) North American Contact Dermatitis Group, 1994-2008 Positive patch test reactions in older individuals: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008 J Am Acad Dermato l66:229-240

Outgoing links (2)

Penicillin; Polymyxin b;

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Last updated on: 29.10.2020