Autoinflammatory syndromes (overview)

Group of inflammatory diseases that are of non-infectious, non-allergic, non-autoimmune and non-immune origin. Auto-inflammatory diseases" include hereditary periodic fever syndromes (HPF) induced by mutations of pattern-recognition receptors (PRR) and disorders of cytokine generation and balance.

A distinction is made:

• Hereditary, periodic fever syndromes

• other hereditary and non-hereditary idiopathic fever syndromes such as:
  • Breastfeeding Syndrome
  • Adult breastfeeding syndrome (AOSD)
  • Schnitzler syndrome (urticarial exanthema)
  • SAPHO syndrome (synovitis, acne, pustulose, hyperostosis, osteitis)
  • PASH syndrome (Pyoderma gangraenosum, acne, suppurative hidradenitis)
  • PAPA syndrome (Pyoderma gangraenosum, acne)
• various autoimmune syndromes as UAW

• Initially the term "autoinflammatory syndromes" was coined for a small group of familial fever syndromes (see below fever syndromes, hereditary, periodic ).
• In the meantime, this term has been extended by an increasing number of acquired diseases.
• In 2010 a drug-induced autoinflammatory syndrome was described, the "autoinflammatory syndrome induced by adjuvants (ASIA)". The "Gulf War Syndrome" also belongs to this syndrome group.
• Such reactions are interpreted asadverse drug reactions(ADRs) that occur as a result of vaccinations (see also AEFI ).

. .

1. Braun-Falco M et al (2011) Skin involvement in autoinflammatory syndromes. SDDG 9: 232 - 245
2. Israeli E (2012) Gulf War syndrome as a part of the autoimmune (autoinflammatory) syndrome induced by adjuvant (ASIA). Lupus 21:190-194.