Autoinflammatory syndromes (overview)

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 04.03.2021

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Synonym(s)

Autoinflammation syndromes; autoinflammatory diseases; autoinflammatory syndromes

History
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Kastner and O'Shea, 1999

Definition
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Group of inflammatory diseases that are non-infectious, non-allergic, non-autoimmune and non-immunodeficient in cause. The term "autoinflammatory diseases" includes the hereditary periodic fever syndromes (HPF), which are induced by mutations of pattern-recognition receptors (PRR) and disturbances of cytokine generation and balance.

Classification
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A distinction is made:

Note(s)
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  • Initially, the term "autoinflammatory syndromes" was coined for a small group of familial fever syndromes (see below Fever syndromes, hereditary, periodic ).
  • This term has since been expanded to include an increasing number of acquired disorders.
  • In 2010, a drug-induced autoinflammatory syndrome was described, the "autoinflammatory syndrome induced by adjuvants (ASIA)". Gulf War Syndrome" also belongs to this group of syndromes.
  • Such reactions are interpreted as adverse drug reactions(ADRs) occurring as a result of vaccination (see also AEFI ) .

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Literature
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  1. Braun-Falco M et al (2011) Skin involvement in autoinflammatory syndromes. SDDG 9: 232 - 245
  2. Israeli E (2012) Gulf War syndrome as a part of the autoimmune (autoinflammatory) syndrome induced by adjuvant (ASIA). Lupus 21:190-194.

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 04.03.2021