Autoinflammatory syndromes (overview)

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 28.07.2022

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Synonym(s)

Autoinflammation syndromes; autoinflammatory diseases; autoinflammatory syndromes

History
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Kastner and O'Shea, 1999

Definition
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Group of inflammatory diseases that are non-infectious, non-allergic, non-autoimmune in nature. The term "autoinflammatory diseases" includes hereditary diseases (e.g. hereditary periodic fever syndromes) induced by mutations of pattern-recognition receptors (PRRs) and disturbances of cytokine generation and balance (see immunodeficiencies primary/autoinflammatory diseases) but also non-hereditary acquired autoinflammatory diseases.

Classification
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Distinguished between:

and

Note(s)
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Initially, the term "autoinflammatory syndromes" was coined for a small group of familial fever syndromes(see below Fever syndromes, hereditary, periodic; see below. Immunodeficiency primary (autoinflammatory diseases). This term has since been expanded to include an increasing number of acquired disorders. In 2010, a drug-induced autoinflammatory syndrome was described, the "autoinflammatory syndrome induced by adjuvants (ASIA)." The "Gulf War Syndrome" also belongs to this acquired group of diseases.

Such reactions are interpreted as adverse drug reactions(ADR) occurring as a consequence of vaccination (see also AEFI ).

Literature
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  1. Braun-Falco M et al (2011) Skin involvement in autoinflammatory syndromes. SDDG 9: 232 - 245
  2. Israeli E (2012) Gulf War syndrome as a part of the autoimmune (autoinflammatory) syndrome induced by adjuvant (ASIA). Lupus 21:190-194.

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 28.07.2022