TNFAIP3 Gene

Last updated on: 23.06.2022

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Definition
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TNFAIP3 (TNF Alpha Induced Protein 3) is a protein coding gene located on chromosome 6q23.3. Multiple transcript variants encoding the same protein have been found for this gene. TNFAIP3 was also characterized as a primary response gene of TNF, IL1-β, and LPS, as each cytokine triggered rapid, transient, and robust induction of the TNFAIP3 transcript independent of de novo protein synthesis.

General information
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The protein encoded by this gene is a zinc finger protein- and ubiquitin-editing enzyme and has been shown to inhibit NF-kappa B activation and TNF-mediated apoptosis. The enzyme exhibits both ubiquitin ligase and deubiquitinase activities, is involved in cytokine-mediated immune and inflammatory responses signaled by cytokines such as TNF-alpha and IL-1 beta or by pathogens via Toll-like receptors (TLRs) by terminating NF-kappa B activity. It is recognized as a key inhibitor of inflammation, cell death and tumorigenesis. In summary, tumor necrosis factor-alpha-induced protein 3 plays a primary role in attenuating pro-inflammatory signaling pathways.

Diseases associated with TNFAIP3 include:

  • Autoinflammatory syndrome, familial, Behcet-like (OMIM: 616744).
  • and
  • Primary mediastinal B-cell lymphoma.

Last updated on: 23.06.2022