Atopic diathesis L20.9

Author: Prof. Dr. med. Peter Altmeyer

Co-Autor: Karl Reinhard

All authors of this article

Last updated on: 29.10.2020

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Definition
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Genetic disposition to the development of atopy. Probably the "atopic gene" does not exist. Rather, it can be assumed that the "atopic genes" belong to the general repertoire of the human genome. Environmental and other factors lead to an overexpression of these genes and to the manifestation of atopic phenomena. Thus, the atopic type should be understood as an "atopic phenotype" rather than an "atopic genotype". A central etiopathogenetic significance in the triggered inflammation cascade is attributed (in contrast to psoriasis) to the production of Th2 cytokines.

In clinical practice, the use of an atopy score is important to obtain firm evidence of atopic eczema.

Occurrence/Epidemiology
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The prevalence of atopic diseases is likely to be around 30%.

Therapy
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Literature
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  1. Arly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium; Australian Asthma Genetics Consortium(AAGC); Australian Asthma Genetics Consortium AAGC (2015)Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet 47:1449-1456
  2. Kumar A etg al. (2015) Genetic association of key Th1/Th2 pathway candidate genes, IRF2, IL6, IFNGR2, STAT4 and IL4RA, with atopic asthma in the Indian population. J Hum Genet 60:443-448
  3. Marenholz I et al (2015) Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat Commun 6:8804
  4. Skabytska Y et al (2015) The role of innate immune signaling in the pathogenesis of atopic dermatitis and consequences for treatments. Semin Immunopathol PubMed PMID: 26573298.

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Last updated on: 29.10.2020