Synonym(s)
APEC; Asymmetrical periflexural exanthem; Asymmetrical periflexural exanthema of childhood; Exanthema asymmetric periflexural; ULE; Unilateral laterothoracic exanthema; Unilateral latero-thoracic exanthema in childhood
HistoryThis section has been translated automatically.
Brunner et al. 1962
DefinitionThis section has been translated automatically.
Self-limiting, 4-6 weeks lasting, probably infect-allergic skin disease of childhood.
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Occurrence/EpidemiologyThis section has been translated automatically.
Very rare occurrence. Mostly in individual children; occasionally in smaller epidemics.
EtiopathogenesisThis section has been translated automatically.
A triggering agent has not yet been described. An infectious or parainfectious genesis in connection with previous viral infections (parovirus B19, parainfluenza 2 viruses, parainfluenza 3 viruses, Epstein-Barr viruses, adenoviruses) is being discussed.
ManifestationThis section has been translated automatically.
Mostly in small children between 6 months and 10 years (average age: 2-3 years). Girls are more frequently affected than boys. The very rare occurrence in adults is described in individual cases. Seasonal accumulation of the occurrence in spring.
LocalizationThis section has been translated automatically.
Thorax, usually beginning in the axillae, then spreading to one half of the trunk, but also upper extremity and buttocks. Occasionally also symmetrical infestation!
Clinical featuresThis section has been translated automatically.
Mostly after infection with mild catarrhal or gastrointestinal symptoms (60% of patients), unilaterally localized exanthema with partly disseminated, partly following the Blaschko lines, maculo-papular, scaly inflammatory efflorescences; occasionally also lichenoid skin lesions; moderate itching (2/3 of cases); accompanying lymphadenopathy possible.
LaboratoryThis section has been translated automatically.
Non-specific
HistologyThis section has been translated automatically.
Non-specific, superficial perivascular lymphocytic dermatitis with mild spongiosis and exocytosis
Differential diagnosisThis section has been translated automatically.
Tinea corporis; drug exanthema; acrodermatitis papulosa eruptiva infantilis (Gianotti-Crosti syndrome); pityriasis rosea, miliaria rubra
TherapyThis section has been translated automatically.
Make parents aware of the harmlessness of the disease pattern; also of the self-limiting course! Antihistamines for itching; bland-nursing external agents.
Progression/forecastThis section has been translated automatically.
Benign course; healing of the exanthema after 3-6 weeks.
LiteratureThis section has been translated automatically.
- Bodemer C, Prost Y (1992) Unilateral laterothoracic exanthem in children: an new disease? J Am Acad Dermatol 27: 693-696
- Brunner MJ et al (1962) A new papular erythema of childhood. Arch Dermatol 85: 539-540
- Mc Cuaig C et al (1996) Unilateral laterothoracic exanthem. J Am Acad Dermatol 34: 979-984
- Peker S et al (2000) Unilateral laterothoracic exanthema. Case report and review of the literature. dermatologist 51: 505-508
- Scott LA et al (2003) Viral exanthems. Dermatol Online J 9: 4
- Strom K et al (1999) Unilateral latero-thoracic exanthema in childhood. Clinical characteristics and diagnostic criteria in 5 patients. dermatologist 50: 39-44
- Taieb A et al (1993) Asymmetric periflexural exanthem of childhood. J Am Acad Dermatol 29: 391-393
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Incoming links (7)
Apec; Asymmetrical periflexural exanthem; Asymmetrical periflexural exanthema of childhood; COVID-19 and skin; Exanthema, asymmetric, periflexural; Paraviral exanthema; Ule;Outgoing links (5)
Adverse drug reactions of the skin; Gianotti-crosti syndrome; Miliaria rubra; Pityriasis rosea; Tinea corporis;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer