HistoryThis section has been translated automatically.
General definitionThis section has been translated automatically.
Saprophytic mould (filamentous fungus) with the ability to form aflatoxin B. Occasionally transmitted through contaminated food, more rarely through contaminated dressings (e.g. plasters, tape, gauze) or intravascular catheters or indwelling cannulas.
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Occurrence/EpidemiologyThis section has been translated automatically.
Worldwide, ubiquitously distributed. Most commonly found in peanuts, spices, oil plants, cereals, and in soil and water. As an opportunistic germ in hospitals mostly occurring in insufficiently filtered ventilation systems, on house plants, floor coverings and food.
Clinical pictureThis section has been translated automatically.
A. flavus occasionally leads to the picture of aspergillosis or disseminated aspergillosis in patients with HIV infection, immunosuppressive therapy, diabetics, organ transplant patients or in the presence of other serious underlying diseases. Patients with severe neutrophilic granulocytopenia are considered particularly at risk. As an inhalation allergen, it is responsible for triggering symptoms of allergic rhinoconjunctivitis, for example.
MicroscopyThis section has been translated automatically.
- Septic hyaline hyphae, distinct air mycelium.
- Conidiophores: numerous, coarse, thick-walled, unseptet, colourless; length: 400-1000 μm, width: 5-15 μm.
- Radially arranged, uniseriate phialides directly connected to the conidial head or biseriate phialides connected to the conidial head via metulae.
- Conidia: Round, colourless to yellowish-green, irregular surface with pits, spines or pigmentation, size: 2-5 μm Ø, distinct expression of conidial heads ("dandelion").
LiteratureThis section has been translated automatically.
- Correa ME et al (2003) Primary aspergillosis affecting the tongue of a leukemic patient. Oral Dis 9: 49-53
- Malnick SD et al (2000) Early diagnosis of invasive aspergillosis. Lancet 355: 2076-2077
- Marroni M et al (2001) Aspergillus flavus infection of an aortic bypass. Eur J Clin Microbiol Infect Dis 20: 439-441
- Myoken Y et al (2003) Molecular epidemiology of invasive stomatitis due to Aspergillus flavus in patients with acute leukemia. J Oral Catholic Med 32: 215-218
- Pitt JI (2000) Toxigenic fungi: which are important? Med Mycol 38 (Suppl 1): 17-22
- Tarrand JJ et al (2003) Diagnosis of invasive septate mold infections. A correlation of microbiological culture and histologic or cytologic examination. At J Clin Pathol 119: 854-858
- Vandecasteele SJ et al (2002) Diagnosis and treatment of Aspergillus flavus sternal wound infections after cardiac surgery. Clin Infect Dis 35: 887-890
- Wong J et al (2001) Coexistent cutaneous Aspergillus and cytomegalovirus infection in a liver transplant recipient. J Am Acad Dermatol 44: 370-372
Outgoing links (6)Allergen; Allergic rhinoconjunctivitis; Aspergillosis; Aspergillosis disseminated; Hiv infection; Moulds;
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