Antiandrogen-oestrogen combinations

Oral contraceptives with antiandrogenic activity, e.g. consisting of ethinyl estradiol and cyproterone acetate.

Hormonal contraception, androgen-dependent diseases in women, such as acne papulopustulosa, acne conglobata, seborrhea, milder forms of hirsutism, alopecia androgenetica (see alopecia androgenetica in women, alopecia androgenetica in men).

• Breastfeeding, discontinue 6 weeks before planned operations, long-term immobilization (e.g. after accidents), smokers > 30 years, liver diseases (e.g. porphyria), Z.n. thrombophlebitis.
• Monitoring in diabetes mellitus, hypertension, varicosis, phlebitis, otosclerosis, multiple sclerosis, epilepsy, minor chorea, latent tetany; women > 40 years.

From 5th to 26th cycle day 1 Drg./day p.o.

visual and hearing disorders, weight gain, chest tensions, changes in libido, thrombosis, gastrointestinal problems, liver tumours, chloasma, blood pressure increase, dizziness, headaches, depression.

See Table 1.

Pregnancy, idiopathic icterus or severe pruritus (in the medical history), severe liver dysfunction, Dubin-Johnson or Rotor syndrome, previous or existing liver tumours, lipid metabolism disorders, Z. n. thrombosis or embolism, Z.n. apoplexy, Z.n. myocardial infarction, tendency to thrombosis, sickle cell anaemia, pemphigoid gestationis (in the medical history), worsening of otosclerosis in pregnancy, severe diabetes mellitus, migraine, severe forms of hypertension, breast or endometrial carcinoma.

Diane 35, Climen

Essential interactions of antiandrogen-estrogen combinations

Antidiabetics, oral	Carbohydrate Tolerance ↓
Barbiturates	contraceptive effect ↓
Broad spectrum antibiotics	contraceptive effect ↓
Carbamazepine	contraceptive effect ↓
Phenytoin	contraceptive effect ↓
Rifampicin	contraceptive effect ↓