Antiandrogen-oestrogen combinations

Last updated on: 29.10.2020

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Definition
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Oral contraceptives with antiandrogenic activity, e.g. consisting of ethinyl estradiol and cyproterone acetate.

Indication
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Hormonal contraception, androgen-dependent diseases in women, such as acne papulopustulosa, acne conglobata, seborrhea, milder forms of hirsutism, alopecia androgenetica (see alopecia androgenetica in women, alopecia androgenetica in men).

Limited indication
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  • Breastfeeding, discontinue 6 weeks before planned operations, long-term immobilization (e.g. after accidents), smokers > 30 years, liver diseases (e.g. porphyria), Z.n. thrombophlebitis.
  • Monitoring in diabetes mellitus, hypertension, varicosis, phlebitis, otosclerosis, multiple sclerosis, epilepsy, minor chorea, latent tetany; women > 40 years.

Dosage and method of use
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From 5th to 26th cycle day 1 Drg./day p.o.

Undesirable effects
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visual and hearing disorders, weight gain, chest tensions, changes in libido, thrombosis, gastrointestinal problems, liver tumours, chloasma, blood pressure increase, dizziness, headaches, depression.

Interactions
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See Table 1.

Contraindication
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Pregnancy, idiopathic icterus or severe pruritus (in the medical history), severe liver dysfunction, Dubin-Johnson or Rotor syndrome, previous or existing liver tumours, lipid metabolism disorders, Z. n. thrombosis or embolism, Z.n. apoplexy, Z.n. myocardial infarction, tendency to thrombosis, sickle cell anaemia, pemphigoid gestationis (in the medical history), worsening of otosclerosis in pregnancy, severe diabetes mellitus, migraine, severe forms of hypertension, breast or endometrial carcinoma.

Preparations
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Diane 35, Climen

Tables
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Essential interactions of antiandrogen-estrogen combinations

Antidiabetics, oral

Carbohydrate Tolerance ↓

Barbiturates

contraceptive effect ↓

Broad spectrum antibiotics

contraceptive effect ↓

Carbamazepine

contraceptive effect ↓

Phenytoin

contraceptive effect ↓

Rifampicin

contraceptive effect ↓

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Last updated on: 29.10.2020