Amoxicillin/clavulanic acid

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Combination preparation of the β lactamase inhibitor clavulanic acid with amoxicillin.

Half-life
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1 h

Indication
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Infections by amoxicillin-sensitive and resistant pathogens, if the resistance is based on the formation of β lactamases.

Limited indication
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Pregnancy, nursing.

Dosage and method of use
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  • 3.6-6.6 g/day i.v. in 3 ED or 1.8-3.6 g/day p.o. in 3 ED
  • Children: 60 mg/kg bw/day i.v. in 3 cycles or 37.5-75 mg/kg bw/day p.o. in 3 cycles.

Undesirable effects
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Interactions
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S.u. Benzylpenicillin. Decreasing the effect of aminoglycosides and increasing the side effects of disulfiram.

Contraindication
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Penicillin allergy, infectious mononucleosis and other viral infections (increased risk of exanthema!), leukemias.

Remember! Amoxicillin/clavulanic acid is contraindicated in patients who have already had liver dysfunction during previous therapy.

Preparations
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Augmentan

Note(s)
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The use of amoxicillin/clauvlanic acid in patients with pre-existing liver dysfunction and in elderly patients over 60 years of age should be used with great caution due to the risk of possible side effects. A regular laboratory check of the liver values is recommended. Relatively high rate of exanthema in the whole group (also in combination with ß-lactamase inhibitor).

Literature
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  1. Larrey D et al (1992)Hepatitis associated with amoxycillin-clavulanic acid combination report of 15 cases. Well 33: 368-371.

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Last updated on: 29.10.2020