Amantadine

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Definition
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Dopamine agonist.

Indication
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Usually M. Parkinson's, extrapyramidal disorders. In dermatology especially for post-zoster neuralgia.

Limited indication
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Lactation period, children < 12 months, age > 65 years, heart failure, hypotension, myasthenia gravis, peripheral edema, tachycardia, narrow-angle glaucoma.

Dosage and method of use
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Initially 100-200 mg/day p.o., after 1 week 2-3 times/day 100-150 mg.

Undesirable effects
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Allergic skin reactions, livedo reticularis, cutis marmorata, CNS disorders, dizziness, visual disorders, photophobia, drop in blood pressure, cardiac arrhythmia, dyspnoea, leukopenia, loss of appetite, dry mouth, nausea.

Notice! Cross-allergy to Tromantadin!

Interactions
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s. Table 1.

Contraindication
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Hypersensitivity to the active substance, pregnancy, delirium, predelirium, narrow-angle glaucoma, epilepsy, mental illness, severe liver and kidney disease, prostate hypertrophy.

Preparations
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PK-Merz

Literature
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  1. Gibbs MB et al (2005) Livedo reticularis: an update. J Am Acad Dermatol 52: 1009-1019

Tables
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Interactions of amantadine

Alcohol

Alcohol tolerance ↓, mutual toxicity ↑

Amfepramon

Delirium

Anticholinergics

nightmares, hallucinations

Appetite suppressant

Mutual toxicity ↑

L-Dopa

mutual effect ↑

Fenproporex

Mutual toxicity ↑

Ipratropium bromide

anticholinergic effect ↑

Mazindol

Mutual toxicity ↑

Mefenorex

Mutual toxicity ↑

Memantine HCl

Mutual toxicity ↑

Mephentermin-HCl

Mutual toxicity ↑

Mequitazine

Amantadine effect ↓

D-norpseudoephedrine

Mutual toxicity ↑

Pentorex

Mutual toxicity ↑

L-Propylhexedrine

Mutual toxicity ↑

Propantheline Bromide

anticholinergic effect ↑

Scopolamine

anticholinergic effect ↑

Selegiline HCl

Amantadine toxicity ↑

Sympathomimetics

Mutual toxicity ↑

Tromantadine HCl

Cross Allergy

Authors

Last updated on: 29.10.2020