Amantadine

Definition
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Dopamine agonist.

Indication
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Usually M. Parkinson's, extrapyramidal disorders. In dermatology especially for post-zoster neuralgia.

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Dermatology

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Limited indication
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Lactation period, children < 12 months, age > 65 years, heart failure, hypotension, myasthenia gravis, peripheral edema, tachycardia, narrow-angle glaucoma.

Dosage and method of use
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Initially 100-200 mg/day p.o., after 1 week 2-3 times/day 100-150 mg.

Undesirable effects
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Allergic skin reactions, livedo reticularis, cutis marmorata, CNS disorders, dizziness, visual disorders, photophobia, drop in blood pressure, cardiac arrhythmia, dyspnoea, leukopenia, loss of appetite, dry mouth, nausea.

Notice! Cross-allergy to Tromantadin!

Interactions
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s. Table 1.

Contraindication
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Hypersensitivity to the active substance, pregnancy, delirium, predelirium, narrow-angle glaucoma, epilepsy, mental illness, severe liver and kidney disease, prostate hypertrophy.

Preparations
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PK-Merz

Literature
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Gibbs MB et al (2005) Livedo reticularis: an update. J Am Acad Dermatol 52: 1009-1019

Tables
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Interactions of amantadine

Alcohol	Alcohol tolerance ↓, mutual toxicity ↑
Amfepramon	Delirium
Anticholinergics	nightmares, hallucinations
Appetite suppressant	Mutual toxicity ↑
L-Dopa	mutual effect ↑
Fenproporex	Mutual toxicity ↑
Ipratropium bromide	anticholinergic effect ↑
Mazindol	Mutual toxicity ↑
Mefenorex	Mutual toxicity ↑
Memantine HCl	Mutual toxicity ↑
Mephentermin-HCl	Mutual toxicity ↑
Mequitazine	Amantadine effect ↓
D-norpseudoephedrine	Mutual toxicity ↑
Pentorex	Mutual toxicity ↑
L-Propylhexedrine	Mutual toxicity ↑
Propantheline Bromide	anticholinergic effect ↑
Scopolamine	anticholinergic effect ↑
Selegiline HCl	Amantadine toxicity ↑
Sympathomimetics	Mutual toxicity ↑
Tromantadine HCl	Cross Allergy