DefinitionThis section has been translated automatically.
Skin change occurring in sun-exposed areas of older people, predominantly with light complexion, characterised by increased wrinkling and irregular pigmentation (see below Lentigo solaris). A coarse follicular structure (with possible keration retentions) and a shiny, whitish protruding interfollicular skin is usually noticeable.
Clinical featuresThis section has been translated automatically.
Increased wrinkle formation, partly with rhomboid skin fields and irregular pigmentation. In advanced stages of the disease, the skin is cloggy with black follicular horn retentions, possibly paired with hypertrichosis (see below elastoidosis cutanea nodularis et cystica). Frequently combination damage in aged skin (photoaging + intrinsic chronological aging).
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HistologyThis section has been translated automatically.
The target cells of chronic light damage are melanocytes, keratinocytes and fibroblasts. In pronounced actinic elastosis, a cloddy basophilic degeneration of the elastic fibre systems(elastin) is found under an atrophic epidermis. This initially affects the upper and adjacent middle dermis. Instead of a structured texture of the elastic fibres, depending on the degree of damage, there are either thickened, irregularly interwoven fibre bundles which stain like elastic material. In advanced stages, only amorphous, basophilic conglomerates are found in the upper, middle and deep dermis.
Direct ImmunofluorescenceThis section has been translated automatically.
External therapyThis section has been translated automatically.
Prevention: Textile and physical/chemical light protection (e.g. Anthelios®).
- Successes with creams containing vitamin A acids (e.g. Cordes VAS cream; Tazarotene 0.1%) or glycolic acid-containing topicals (e.g. Neostrata, Neotop, Avène) have been described.
- Skin care with greasy external agents like e.g. ash base cream, linola milk, linola fat cream, excipial almond oil ointment.
- Caution: Attention should be paid to the occurrence of melanocytic or non-melanocytic malignancies.
LiteratureThis section has been translated automatically.
- Bosset S et al (2002) Skin ageing: clinical and histopathologic study of permanent and reducible wrinkles. Eur J Dermatol 12: 247-252
- Calderone DC et al (1995) The clinical spectrum of actinic elastosis. J Am Acad Dermatol 32: 1016-1024
- David M et al (2005) Actinic damage among patients with psoriasis treated by climatotherapy at the Dead Sea. J Am Acad Dermatol 52(3Pt1): 445-450
- Edwards C et al (2003) A study of differences in surface roughness between sun-exposed and unexposed skin with age. Photodermatol Photoimmunol Photomed 19: 169-174
- Gambichler T, Altmeyer P, piece M (2005) Cerebriform elastoma: an unusual presentation of actinic elastosis. J Am Acad Dermatol 52: 1106-1108
- Kang S et al (2004) A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage. J Am Acad Dermatol 52: 268-274
- Ohnishi Y et al (2000) Expression of elastin-related proteins and matrix metalloproteinases in actinic elastosis of sun-damaged skin. Arch Dermatol Res 292: 27-31
- Tanaka N et al (2001) Immunohistochemical detection of lipid peroxidation products, protein-bound acrolein and 4-hydroxynonenal protein adducts, in actinic elastosis of photodamaged skin. Arch Dermatol Res 293: 363-367
Incoming links (22)Albinism oculocutaneous tyrosinase-negative; Atrophy senile of the skin; Basal cell carcinoma sclerodermiformes; Camouflage; Collagen degeneration, basophilic; Diffuse elastoma; Ear knot, elastic; Elastic fibres; Elastosis; Elastosis, senile; ... Show all
Outgoing links (4)Elastin; Elastoidosis cutanea nodularis et cystica; Lentigo solaris; Light protection;
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