Acral fibromyxoma D 48.-

Fetsch et al. 2001

Rare, fibroblastically differentiated, myxoidal tumor of the skin which occurs mainly in the digital acra, here preferably periungual (more rarely subungual).

m:f=1.3:1.0;

The age of manifestation ranged from 4-86 years (median 49 years).

In larger collectives (Hollmann 2012) 52% were located on the hands, 45% on the feet, and occasionally on the ankles and lower legs. > 95% of the neoplasms were sub- or periungual.

Slowly growing over months or years, mostly periungual and leading to nail dystrophies, 0.5-5.0 cm in size (median 1.5 cm), often painful papules or nodules.

Unencapsulated myxoid neoplasm from spindle-shaped moderately nuclear and cellular polymorphs, CD34-positive fibroblasts, mixed with mast cells. Mitoses are missing. Sometimes also groups of multinuclear giant cells. Focal numerous blood vessels. Very rarely expression of alpha-smooth muscular actin and desmin. S-100 protein neg.

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2. Fetsch JF et al (2001) Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of distinctive soft tissue tumor with a predilection for the fingers and toes. Hum Pathol 32: 704-714
3. Hollmann TJ et al (2012) Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases. On J Surg Pathol 36:789-798.
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