Acetylcysteine

Definition
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Mucolytic, expectorant, antioxidant.

Half-life
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6,25 h

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Indication
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Expectoration promotion in acute and chronic bronchopulmonary diseases. In high doses, ACC can be used as an antidote for paracetamol poisoning.

Limited indication
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Pregnancy, lactation, bronchial asthma, encephalopathy, neonates and children < 12 months.

Dosage and method of use
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Promotion of expectoration: 3 times 200 mg/day p.o. or once/day 600 mg or 1-2 times/day 300 mg by inhalation or 1-2 times/day 300 mg slowly i.v. or i.m.; children receive half the dose!
Paracetamol poisoning: Start within 16 hours after intoxication: Initial 150 mg/kg bw in 200 ml 5% glucose solution i.v. for 15 minutes, then 50 mg/kg bw in 500 ml 5% glucose with electrolyte addition for 4 hours and 100 mg/kg bw in 1000 ml 5% glucose with electrolyte addition for 16 hours.

Undesirable effects
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See table.

Interactions
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See table.

Contraindication
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Hypersensitivity to the active substance.

Preparations
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ACC, Bisolvon, Bromuc, Fluimucil, Siran, Stas

Patientinformation
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It is important to ensure a sufficient supply of liquid, as this is the basis of the expectoration-promoting effect!

Tables
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Airways	bronchospasm, dyspnoea, rhinitis Hemoptysis
Blood, lymph	anaemia, thrombocyte aggregation inhibition
GIT	Nausea, vomiting, diarrhoea
Urinary tract	Immunocomplex nephritis
Skin	allergic reactions (pruritus, exanthema, urticaria, Stevens-Johnson syndrome, angioedema) Stomatitis drug-induced lupus erythematosus
Cardiovascular	facial edema, hypotension, anaphylactic shock
Nervous System	Headaches
Sense Organs	Tinnitus

Ampicillin	Ampicillin effect ↓, Ampicillin intake delayed for 2 hours
Antitussives	Secretory congestion, avoid combination
Carindacillin	Carindacillin effect ↓, Carindacillin 2 hours delayed intake
Cefaclor	Cefaclor effect ↓, Cefaclor 2 hours delayed intake
Cefadroxil	Cefadroxil effect ↓, Cefadroxil 2 hours delayed intake
Cefalexin	Cefalexin-Wikung ↓, Cefalexin 2 hours delayed intake
Cefixim	Cefixim effect ↓, Cefixim 2 hours delayed intake
Cefradine	Cefradin effect ↓, Cefradin intake delayed for 2 hours
Codeine	Secretory congestion, avoid combination
Epicillin	Epicillin effect ↓, Epicillin 2 hours delayed intake
Glycerol trinitrate	vasodilatory and antiplatelet aggregation effect ↑
Hydrocodone	Secretory congestion, avoid combination

Incoming links (1)

Measles;

Outgoing links (1)

Paracetamol;

Authors

Last updated on: 30.09.2022

Author: Prof. Dr. med. Peter Altmeyer

Definition This section has been translated automatically.

Half-life This section has been translated automatically.

You might also be interested in

Indication This section has been translated automatically.

Limited indication This section has been translated automatically.

Dosage and method of use This section has been translated automatically.

Undesirable effects This section has been translated automatically.

Interactions This section has been translated automatically.

Contraindication This section has been translated automatically.

Preparations This section has been translated automatically.

Patientinformation This section has been translated automatically.

Tables This section has been translated automatically.

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