Acetylcysteine

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Definition
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Mucolytic, expectorant, antioxidant.

Half-life
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6,25 h

Indication
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Expectoration promotion in acute and chronic bronchopulmonary diseases. In high doses, ACC can be used as an antidote for paracetamol poisoning.

Limited indication
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Pregnancy, lactation, bronchial asthma, encephalopathy, newborns and children < 12 months.

Dosage and method of use
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  • Promotion of expectoration: 3 times 200 mg/day p.o. or once/day 600 mg or 1-2 times/day 300 mg by inhalation or 1-2 times/day 300 mg slowly i.v. or i.m.; children receive half the dose!
  • Paracetamol poisoning: Start within 16 hours after intoxication: Initial 150 mg/kg bw in 200 ml 5% glucose solution i.v. for 15 minutes, then 50 mg/kg bw in 500 ml 5% glucose with electrolyte addition for 4 hours and 100 mg/kg bw in 1000 ml 5% glucose with electrolyte addition for 16 hours.

Undesirable effects
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See table.

Interactions
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See table.

Contraindication
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Hypersensitivity to the active substance.

Preparations
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ACC, Bisolvon, Bromuc, Fluimucil, Siran, Stas

Patientinformation
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It is important to ensure a sufficient supply of liquid, as this is the basis of the expectoration-promoting effect!

Tables
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Airways

bronchospasm, dyspnoea, rhinitis

Hemoptysis

Blood, lymph

anaemia, thrombocyte aggregation inhibition

GIT

Nausea, vomiting, diarrhoea

Urinary tract

Immunocomplex nephritis

Skin

allergic reactions (pruritus, exanthema, urticaria, Stevens-Johnson syndrome, angioedema)

Stomatitis

drug-induced lupus erythematosus

Cardiovascular

facial edema, hypotension, anaphylactic shock

Nervous System

Headaches

Sense Organs

Tinnitus


Ampicillin

Ampicillin effect ↓, Ampicillin intake delayed for 2 hours

Antitussives

Secretory congestion, avoid combination

Carindacillin

Carindacillin effect ↓, Carindacillin 2 hours delayed intake

Cefaclor

Cefaclor effect ↓, Cefaclor 2 hours delayed intake

Cefadroxil

Cefadroxil effect ↓, Cefadroxil 2 hours delayed intake

Cefalexin

Cefalexin-Wikung ↓, Cefalexin 2 hours delayed intake

Cefixim

Cefixim effect ↓, Cefixim 2 hours delayed intake

Cefradine

Cefradin effect ↓, Cefradin intake delayed for 2 hours

Codeine

Secretory congestion, avoid combination

Epicillin

Epicillin effect ↓, Epicillin 2 hours delayed intake

Glycerol trinitrate

vasodilatory and antiplatelet aggregation effect ↑

Hydrocodone

Secretory congestion, avoid combination

Incoming links (1)

Measles;

Outgoing links (1)

Paracetamol;

Authors

Last updated on: 29.10.2020