DefinitionThis section has been translated automatically.
Protein family whose members function as "water channels" in animal and plant cells. In mammals, aquaporins (AQP1) regulate the water balance of e.g. erythrocytes, kidney cells, keratinocytes and other cells. An erythrocyte, for example, has about 200,000 water channels per cell. In the alveoli, such "channels" provide the fluid film necessary for gas exchange. Malfunctions of the aquaporins are responsible for diseases such as diabetes insipidus, atopic eczema, cataracts and glaucoma. Aquaporin-3 is expressed more frequently in atopic eczema. This would be among others an explanation for the disturbance of the barrier function in atopics. Retinoids are also able to upregulate AQPs.
ClassificationThis section has been translated automatically.
- Aquaporins are divided into:
- so-called common aquaporins
- Aquaglyceroporins conduct water as well as small organic molecules such as glycerol or urea.
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General informationThis section has been translated automatically.
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LiteratureThis section has been translated automatically.
- Hara-Chikuma et al (2008) Roles of aquaporin-3 in the epidermis. J Invest Dermatol 128: 2145-2151.