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Notice! Neither test is particularly conclusive. The diagnosis is made clinically!
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- Immediately discontinue the triggering drug and avoid all drugs that are broken down by cytochrome P450. Otherwise, avoid symptomatic therapy, liver- and kidney-damaging drugs. If necessary, intensive care measures are necessary.
Remember! Cross-reactivity between the different anticonvulsants: carbamazepine, phenytoin and phenobarbital! If the metabolic defect situation is not recognized, there is a risk that carbamazepine is converted to e.g. phenytoin, which may lead to life-threatening symptoms!
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- Aihara Y et al (2003) Carbamazepine-induced hyperyensitivita syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction. Br J Dermatol 149: 165-169
- Baba M et al (2003) The anticonvulsant hypersensitivity syndrome. J Eur Acad Dermatol Venereol. 17: 399-401
- Descamps V (2003) Drug-induced hypersensitivity syndrome associated with Epstein-Barr virus infection. Br J Dermatol 148: 1032-1034
- Gall H (1991) Anticonvulsant hypersensitivity syndrome on carbamazepine. Clin Pharmacokinet 21:195-212
- Huang YL et al (2003) Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis. J Am Acad Dermatol 49: 316-319
- Niketic V, Ristic S, Saicic ZS et al (1995) Activities of antioxidant enzymes and formation of the glutathione adduct of hemoglobin (Hb ASSG) in epileptic patients with long-term antiepileptic therapy. Farmaco 50: 811-813
- Shear NH, Spielberg SP (1988) Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. J Clin Invest 82: 1826-1832
- Vittorio CC, Muglia JJ (1995): Anticonvulsant hypersensitivity syndrome. Arch Internal Med155: 2285-2290
- Petter G, Haustein UF (1999) Stevens-Johnson syndrome with transition to toxic epidermal necrolysis after carbamazepine administration, heroin and alcohol abuse. dermatologist 50: 884-888
- Verrotti A (2002) Anticonvulsant hypersensitivity syndrome in children: incidence, prevention and management. CNS Drugs 16: 197-205
Outgoing links (10)Allopurinol; Calcium antagonists, side effects; Carbamazepine; Cytomegalovirus; Dadps; Lymphocyte transformation test; Minocycline; Phenobarbital; Phenytoin; Terbinafine;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.