Synonym(s)
TAFI
DefinitionThis section has been translated automatically.
This factor antagonizes fibrinolysis by stabilizing fibrin induced by the thrombin-thrombomodulin complex. It is a carboxylase that cleaves off lysine and arginine residues at the fibrin and thus inhibits the binding of the plasma to the fibrin.
In 2006, a mutation of TAFI was described which has a half-life 180 times longer than that of normal TAFI and thus shows a significantly increased antifibrinolytic effect.
LiteratureThis section has been translated automatically.
- HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 113.
Prof. Dr. med. Peter Altmeyer