Protein z defects - Altmeyers Encyclopedia - Department Vascular medicine

Definition
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Polymorphisms of the protein Z and disturbances of the protein Z-dependent protease lead to an increased tendency to thrombosis and more often to apoplexies.

Etiopathogenesis
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Protein Z acts as a cofactor for the binding of thrombin to the phospholipid surface, thus promoting clotting. On the other hand, it is involved in the degradation of F-Xa. If this function is disturbed, it can lead to an increased tendency to thrombosis and apoplexies.