Plasmine/plasminogen deficiency

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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This is a congenital, autosomal-recessive inherited deficiency of plasminogen, the precursor of plasmin. Due to this deficiency, too little plasmin is available for endogenous fibrinolysis. There may also be genetic defects in the plasmin that lead to reduced functions (dys-forms). Many genetic variants of such plasminogen mutations have been described, named after the cities of their discovery.

Occurrence/Epidemiology
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This defect is found in 2-3% of young patients with deep vein thrombosis.

Literature
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  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin S. 232.

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020