Hipaa

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Heparin induced platelet activation assay; Heparin-induced platelet activation test; HIPA

Definition
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HIPAA is the acronym for "heparin induced platelet activation assay". This test detects HIT antibodies against various antigens. However, only IgG class antibodies are detected.

In this test washed platelets from healthy donors are incubated with the patient's serum and low (0.2IU/ml) and high (100IU/ml) heparin concentrations.

General information
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Platelet activation at low but not high heparin concentrations is typical for HIT. Activation is measured as the release of radioactive serotonin (serotonin release test), oider visually (HIPA test).

Literature
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  1. Greinacher T (2008) Thrombocytopenia and platelet dysfunction. In: Thomas L (Ed) Laboratory and diagnosis. Th-Books Publishing Company Ltd, Frankfurt/Main p. 918

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Last updated on: 29.10.2020