Pyrazinamide
Definition
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Half-life
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6 h
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Indication
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Combination therapy of tuberculosis.
Dosage and method of use
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30-35 mg/kg bw/day p.o. for at least 6 months.
Undesirable effects
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photosensitization, gastrointestinal disorders, liver damage, hyperuricemia, hematopoiesis disorders, anorexia, flush, urticaria.
Interactions
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Uricosurics or static and ascorbic acid reduce uric acid excretion. Increased blood sugar reduction when taking oral antidiabetics.
Contraindication
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Pregnancy, lactation, severe liver dysfunction.
Preparations
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Pyrafat
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Prof. Dr. med. Peter Altmeyer
