Synonym(s)
Carboplatinum
DefinitionThis section has been translated automatically.
Platinum derivative of the second generation with alkylating effect on the DNA of tumour cells ( alkylans) for use as a cytostatic drug.
Pharmacodynamics (Effect)This section has been translated automatically.
Intracellular activation to release reactive platinum complexes. Binding to nucleophilic groups e.g. GC-rich DNA sequences. This creates DNA cross-links and DNA-protein links that lead to apoptosis and cell growth inhibition.
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IndicationThis section has been translated automatically.
Approved for the treatment of advanced epithelial ovarian cancer and small cell lung cancer.
Malignant melanoma ( off-label use).
Pregnancy/nursing periodThis section has been translated automatically.
Contraindicated.
Dosage and method of useThis section has been translated automatically.
400 mg/m2 KO i.v. as infusion over 15-60 minutes.
Undesirable effectsThis section has been translated automatically.
Systemic ADRs:
- Thrombocytopenia and other blood formation disorders
- gastrointestinal disorders
- Toxic liver damage
- Renal damage
- Cardiac arrhythmia
- neurological disorders, visual, hearing and taste disorders
- Disorders of spermatogenesis and ovulation.
Cutaneous ADRs (listed according to their frequency):
- Alopecia
- Pruritus
- Exantheme
- Stomatitis(mucositis)
- allergic reactions up to anaphylactic shock
- Stevens-Johnson syndrome
- Raynaud's Syndrome
- Skin necroses after intra-arterial application.
PreparationsThis section has been translated automatically.
Carboplatinum Hexal®, Carboplatinum ratiopharm®
Prof. Dr. med. Peter Altmeyer